来自结肠成纤维细胞分泌组蛋白质组学分析的数据。
Data from a proteomic analysis of colonic fibroblasts secretomes.
作者信息
Chen Sun-Xia, Xu Xiao-En, Wang Xiao-Qing, Cui Shu-Jian, Xu Lei-Lei, Jiang Ying-Hua, Zhang Yang, Yan Hai-Bo, Zhang Qian, Qiao Jie, Yang Peng-Yuan, Liu Feng
机构信息
Department of Medical Systems Biology of School of Basic Medical Sciences and Institutes of Biomedical Sciences, Fudan University, 131 Dongan Road, Shanghai 200032, China.
出版信息
Data Brief. 2014 Aug 21;1:19-24. doi: 10.1016/j.dib.2014.08.003. eCollection 2014 Dec.
The tumor cell proliferation, migration and invasion were influenced by the interaction between the cancer cells and their microenvironment. In current study, we established two pairs of the primary fibroblast cultures from colorectal adenocarcinoma tissues and the normal counterparts and identified 227 proteins in the colonic fibroblast secretomes; half of these proteins were novel. The mass spectrometry data and analyzed results presented here provide novel insights into the molecular characteristics and modulatory role of colon cancer associated fibroblasts. The data is related to "Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation" by Chen et al. [1].
肿瘤细胞的增殖、迁移和侵袭受到癌细胞与其微环境之间相互作用的影响。在本研究中，我们从结直肠癌组织及其正常对应组织中建立了两对原代成纤维细胞培养物，并在结肠成纤维细胞分泌组中鉴定出227种蛋白质；其中一半是新发现的蛋白质。本文展示的质谱数据和分析结果为结肠癌相关成纤维细胞的分子特征和调节作用提供了新的见解。这些数据与Chen等人发表的《结肠成纤维细胞分泌组的鉴定揭示了调节结肠癌细胞增殖的分泌因子》[1]相关。
Zotero 插件