Brioschi Maura, Lento Sabrina, Barcella Simona, Nasim Md Talat, Ghilardi Stefania, Barbieri Silvia Stella, Tremoli Elena, Banfi Cristina
Centro Cardiologico Monzino IRCCS, Milano, Italy.
National Institute for Health Research Comprehensive Biomedical Research Centre, King׳s College London, UK ; Department of Medical and Molecular Genetics, King׳s College London, UK ; Bradford School of Pharmacy, School of Life Sciences, University of Bradford, UK.
Data Brief. 2015 Feb 25;3:117-9. doi: 10.1016/j.dib.2015.02.005. eCollection 2015 Jun.
This data article is related to the research article entitled Proteomics of Tissue Factor silencing in cardiomyocytic cells reveals a new role for this coagulation factor in splicing machinery control by Lento et al. [1]. Tissue Factor (TF) is a key player in the coagulation cascade, but it has additional functions ranging from angiogenesis, tumour invasion and, in the heart, the maintenance of the integrity of cardiac cells. This article reports the nano-LC-MS(E) analysis of the cardiomyocytic HL-1 cell line proteome and describes the results obtained from a Gene Ontology analysis of those proteins affected by TF-gene silencing.
本数据文章与Lento等人发表的题为《心肌细胞中组织因子沉默的蛋白质组学揭示了这种凝血因子在剪接机制控制中的新作用》的研究文章相关[1]。组织因子（TF）是凝血级联反应中的关键因子，但它还具有其他功能，包括血管生成、肿瘤侵袭，以及在心脏中维持心肌细胞的完整性。本文报道了心肌细胞HL-1细胞系蛋白质组的纳升液相色谱-质谱/质谱（nano-LC-MS(E)）分析，并描述了对受TF基因沉默影响的蛋白质进行基因本体分析所获得的结果。
