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用于亲和标记的青蒿素生物素化探针的合成。

Synthesis of biotinylated probes of artemisinin for affinity labeling.

作者信息

Konziase Benetode

机构信息

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.

出版信息

Data Brief. 2015 May 5;4:66-74. doi: 10.1016/j.dib.2015.04.017. eCollection 2015 Sep.

DOI:10.1016/j.dib.2015.04.017
PMID:26217765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4510398/
Abstract

In this data article, we described the synthetic routes to four biotinylated probes (2, 3, 4, and 5) of artemisinin and the associated experimental procedures. We also provided the physical data for the synthesized compounds. These synthesized biotinylated probes of artemisinin are useful molecular tools for the affinity-labeling study of target receptor proteins of artemisinin in tropical pathogens such as Trypanosoma, Leishmania, and Schistosoma. The data provided herein are related to "Biotinylated probes of artemisinin with labeling affinity toward Trypanosoma brucei brucei target proteins", by Konziase (Anal. Biochem. (2015)).

摘要

在本数据文章中，我们描述了青蒿素的四种生物素化探针（2、3、4和5）的合成路线以及相关实验步骤。我们还提供了合成化合物的物理数据。这些合成的青蒿素生物素化探针是用于对热带病原体（如布氏锥虫、利什曼原虫和血吸虫）中青蒿素靶标受体蛋白进行亲和标记研究的有用分子工具。本文提供的数据与Konziase的《对布氏布氏锥虫靶标蛋白具有标记亲和力的青蒿素生物素化探针》（《分析生物化学》（2015年））相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/4510398/a194c6e61513/sc4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/4510398/fe0d3caeeedd/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/4510398/2dab94c8d18a/sc2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/4510398/7c8713df73d4/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/4510398/a194c6e61513/sc4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/4510398/fe0d3caeeedd/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/4510398/2dab94c8d18a/sc2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/4510398/7c8713df73d4/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/4510398/a194c6e61513/sc4.jpg

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本文引用的文献

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Anal Biochem. 2015 Aug 1;482:25-31. doi: 10.1016/j.ab.2015.04.020. Epub 2015 Apr 23.
2
A novel biotinylated heterobifunctional cross-linking reagent bearing an aromatic diazirine.一种带有芳族重氮丙啶的新型生物素化异双功能交联剂。
Bioorg Med Chem. 1994 Dec;2(12):1367-73. doi: 10.1016/s0968-0896(00)82088-x.