Samanta Jayshree, Salzer James L
New York University Neuroscience Institute, Departments of Physiology and Neuroscience, NYU School of Medicine, New York, NY 10016, USA.
New York University Neuroscience Institute, Departments of Physiology and Neuroscience, NYU School of Medicine, New York, NY 10016, USA.
Dev Cell. 2015 Jul 27;34(2):129-30. doi: 10.1016/j.devcel.2015.07.006.
The mechanisms that drive the spiral wrapping of the myelin sheath around axons are poorly understood. Two papers in this issue of Developmental Cell demonstrate that actin disassembly, rather than actin assembly, predominates during oligodendrocyte maturation and is critical for the genesis of the central myelin sheath.
驱动髓鞘围绕轴突进行螺旋状包裹的机制目前仍知之甚少。本期《发育细胞》杂志上的两篇论文表明，在少突胶质细胞成熟过程中，肌动蛋白的解聚而非组装起主导作用，并且对中枢髓鞘的形成至关重要。
