髓鞘形成：肌动蛋白解聚起引领作用。
Myelination: actin disassembly leads the way.
作者信息
Samanta Jayshree, Salzer James L
机构信息
New York University Neuroscience Institute, Departments of Physiology and Neuroscience, NYU School of Medicine, New York, NY 10016, USA.
New York University Neuroscience Institute, Departments of Physiology and Neuroscience, NYU School of Medicine, New York, NY 10016, USA.
出版信息
Dev Cell. 2015 Jul 27;34(2):129-30. doi: 10.1016/j.devcel.2015.07.006.
Abstract
The mechanisms that drive the spiral wrapping of the myelin sheath around axons are poorly understood. Two papers in this issue of Developmental Cell demonstrate that actin disassembly, rather than actin assembly, predominates during oligodendrocyte maturation and is critical for the genesis of the central myelin sheath.
摘要
驱动髓鞘围绕轴突进行螺旋状包裹的机制目前仍知之甚少。本期《发育细胞》杂志上的两篇论文表明，在少突胶质细胞成熟过程中，肌动蛋白的解聚而非组装起主导作用，并且对中枢髓鞘的形成至关重要。
相似文献
1
Myelination: actin disassembly leads the way.髓鞘形成：肌动蛋白解聚起引领作用。
Dev Cell. 2015 Jul 27;34(2):129-30. doi: 10.1016/j.devcel.2015.07.006.
2
CNS myelin wrapping is driven by actin disassembly.中枢神经系统髓鞘形成由肌动蛋白解聚驱动。
Dev Cell. 2015 Jul 27;34(2):152-67. doi: 10.1016/j.devcel.2015.06.011. Epub 2015 Jul 9.
3
The Actin Cytoskeleton in Myelinating Cells.成髓鞘细胞中的肌动蛋白细胞骨架。
Neurochem Res. 2020 Mar;45(3):684-693. doi: 10.1007/s11064-019-02753-0. Epub 2019 Mar 7.
4
Regulation of oligodendrocyte differentiation and myelination.少突胶质细胞分化和髓鞘形成的调控。
Science. 2010 Nov 5;330(6005):779-82. doi: 10.1126/science.1190927.
5
Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.肌动蛋白丝周转驱动中枢神经系统髓鞘形成过程中前沿的生长。
Dev Cell. 2015 Jul 27;34(2):139-151. doi: 10.1016/j.devcel.2015.05.013. Epub 2015 Jul 9.
6
CaMKIIβ regulates oligodendrocyte maturation and CNS myelination.CaMKIIβ 调节少突胶质细胞成熟和中枢神经系统髓鞘形成。
J Neurosci. 2013 Jun 19;33(25):10453-8. doi: 10.1523/JNEUROSCI.5875-12.2013.
7
Role of the oligodendroglial cytoskeleton in differentiation and myelination.少突胶质细胞细胞骨架在分化和髓鞘形成中的作用。
Glia. 2009 Dec;57(16):1691-705. doi: 10.1002/glia.20885.
8
The oligodendrocyte growth cone and its actin cytoskeleton: A fundamental element for progenitor cell migration and CNS myelination.少突胶质细胞生长锥及其肌动蛋白细胞骨架：祖细胞迁移和中枢神经系统髓鞘形成的基本要素。
Glia. 2020 Jul;68(7):1329-1346. doi: 10.1002/glia.23735. Epub 2019 Nov 7.
9
Mechanical plasticity during oligodendrocyte differentiation and myelination.少突胶质细胞分化和髓鞘形成过程中的机械塑性。
Glia. 2018 Jan;66(1):5-14. doi: 10.1002/glia.23206. Epub 2017 Sep 21.
10
Progressive remodeling of the oligodendrocyte process arbor during myelinogenesis.髓鞘形成过程中少突胶质细胞突起树突的渐进性重塑。
Dev Neurosci. 1996;18(4):243-54. doi: 10.1159/000111414.
引用本文的文献
1
A Novel Lysolecithin Model for Visualizing Damage in the Larval Zebrafish Spinal Cord.一种用于可视化斑马鱼幼体脊髓损伤的新型溶血卵磷脂模型。
Front Cell Dev Biol. 2021 May 20;9:654583. doi: 10.3389/fcell.2021.654583. eCollection 2021.
2
Fibulin 5, a human Wharton's jelly-derived mesenchymal stem cells-secreted paracrine factor, attenuates peripheral nervous system myelination defects through the Integrin-RAC1 signaling axis.纤维连接蛋白5是一种源自人脐带华通氏胶间充质干细胞分泌的旁分泌因子，它通过整合素-RAC1信号轴减轻周围神经系统髓鞘形成缺陷。
Stem Cells. 2020 Oct 27;38(12):1578-93. doi: 10.1002/stem.3287.
3
Sustentacular Cell Enwrapment of Olfactory Receptor Neuronal Dendrites: An Update.支持细胞包裹嗅感觉神经元树突：更新。
Genes (Basel). 2020 Apr 30;11(5):493. doi: 10.3390/genes11050493.
4
EGFR/ErbB Inhibition Promotes OPC Maturation up to Axon Engagement by Co-Regulating PIP2 and MBP.EGFR/ErbB 抑制通过共同调节 PIP2 和 MBP 促进少突胶质前体细胞的成熟直至与轴突结合。
Cells. 2019 Aug 6;8(8):844. doi: 10.3390/cells8080844.
5
Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A.SIPA1L2 变异与 1A 型腓骨肌萎缩症表型修饰相关。
Ann Neurol. 2019 Mar;85(3):316-330. doi: 10.1002/ana.25426.
本文引用的文献
1
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.大脑皮层神经胶质细胞、神经元和血管细胞的 RNA 测序转录组和剪接数据库。
J Neurosci. 2014 Sep 3;34(36):11929-47. doi: 10.1523/JNEUROSCI.1860-14.2014.
2
Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue.髓鞘膜包裹中枢神经系统轴突，通过内舌部的 PI(3,4,5)P3 依赖性极化生长。
Cell. 2014 Jan 16;156(1-2):277-90. doi: 10.1016/j.cell.2013.11.044.
3
Actin dynamics, architecture, and mechanics in cell motility.肌动蛋白动力学、结构和细胞运动中的力学。
Physiol Rev. 2014 Jan;94(1):235-63. doi: 10.1152/physrev.00018.2013.
4
The role and regulation of blebs in cell migration.小泡在细胞迁移中的作用和调控。
Curr Opin Cell Biol. 2013 Oct;25(5):582-90. doi: 10.1016/j.ceb.2013.05.005. Epub 2013 Jun 17.
5
N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination.N-WASp 对于施万细胞细胞骨架动态、正常髓鞘基因表达和周围神经髓鞘形成是必需的。
Development. 2011 Apr;138(7):1329-37. doi: 10.1242/dev.058677.
6
N-WASP is required for membrane wrapping and myelination by Schwann cells.N-WASP 对于施万细胞的膜包裹和髓鞘形成是必需的。
J Cell Biol. 2011 Jan 24;192(2):243-50. doi: 10.1083/jcb.201010013.
7
WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.波形蛋白1（WAVE1）是少突胶质细胞形态发生和中枢神经系统正常髓鞘形成所必需的。
J Neurosci. 2006 May 24;26(21):5849-59. doi: 10.1523/JNEUROSCI.4921-05.2006.
8
Actin plays a role in both changes in cell shape and gene-expression associated with Schwann cell myelination.肌动蛋白在与施万细胞髓鞘形成相关的细胞形态变化和基因表达中均发挥作用。
J Neurosci. 1997 Jan 1;17(1):241-50. doi: 10.1523/JNEUROSCI.17-01-00241.1997.
9
Glial cells and the central myelin sheath.神经胶质细胞与中枢髓鞘。
Physiol Rev. 1968 Jan;48(1):197-251. doi: 10.1152/physrev.1968.48.1.197.
Zotero 插件