Zhou Zhu, Wang Ying, Tan Hua, Bharti Veni, Che Yi, Wang Jun-Feng
Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada; Departments of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada; Medical College of Soochow University, Suzhou, PR China.
Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada; Departments of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.
Neurosci Lett. 2015 Aug 31;603:84-8. doi: 10.1016/j.neulet.2015.07.027. Epub 2015 Jul 26.
A lack of behavioral tests and animal models for manic-depressive bipolar disorder is recognized as an important factor limiting development of novel pharmaceutical treatments for the disorder. Repeated amphetamine-induced hyperactivity is a commonly used animal model for mania. However, hyperactivity represents only one facet of mania and is also seen in other disorders. Increased engagement in risk taking behavior is frequently observed in the manic phase of bipolar disorder. In the present study, we analyzed the effect of the most commonly used mood stabilizer lithium on repeated amphetamine treatment-induced risk-taking behaviors in rats using elevated plus maze and wire-beam bridge tests. We found that repeated amphetamine treatment not only increased locomotor activity, but also increased risk taking behaviors in rats, and further that chronic lithium treatment inhibited the amphetamine-increased risk taking behavior. Our studies suggest that these tests may be useful tools to analyze the pharmacological validity of new and improved anti-manic drugs in animals.
缺乏针对躁郁双相情感障碍的行为测试和动物模型被认为是限制该疾病新型药物治疗发展的一个重要因素。反复给予苯丙胺诱导的多动是一种常用的躁狂动物模型。然而，多动只是躁狂的一个方面，在其他疾病中也会出现。在双相情感障碍的躁狂阶段经常观察到冒险行为增加。在本研究中，我们使用高架十字迷宫和钢丝束桥测试分析了最常用的情绪稳定剂锂对反复给予苯丙胺治疗诱导的大鼠冒险行为的影响。我们发现，反复给予苯丙胺治疗不仅增加了大鼠的运动活动，还增加了冒险行为，并且进一步发现慢性锂治疗抑制了苯丙胺增加的冒险行为。我们的研究表明，这些测试可能是分析新型和改良抗躁狂药物在动物体内药理有效性的有用工具。
