Kreps Elke Olivia, Derveaux Thierry, De Keyser Filip, Kestelyn Philippe
a University Hospital Ghent , Ophthalmology , Ghent , Belgium and.
b University Hospital Ghent , Immunology , Ghent , Belgium.
Ocul Immunol Inflamm. 2016 Jun;24(3):348-57. doi: 10.3109/09273948.2015.1005239. Epub 2015 Jul 29.
Rubella virus (RV) has a central role in the etiopathogenesis of Fuchs' uveitis syndrome (FUS). We aim to offer new insights by comprehensive analysis of recent laboratory and epidemiologic data.
We conducted a literature search for laboratory data and papers on etiopathogenesis.
Aqueous humour samples of FUS patients show immunoreactivity to RV, in a specific and sensitive manner. Identification of RV genome confirm intraocular infection in a subset of FUS patients. Epidemiologic findings further support causality. The clinical spectrum of RV-associated uveitis is similar but not identical to FUS. FUS eyes exhibit a predominance of CD8 + T cells, high IFN-? and IL-10 levels.
RV is the leading cause of FUS. Cytokine-based findings mirror a viral etiology and chronic low-grade inflammation. RV-associated FUS represents a common pathway of intraocular RV inoculation after congenital or acquired infection. Other causes, including HSV and CMV, may lead to FUS.
风疹病毒（RV）在富克斯葡萄膜炎综合征（FUS）的病因发病机制中起核心作用。我们旨在通过对近期实验室和流行病学数据的综合分析提供新的见解。
我们对实验室数据和有关病因发病机制的论文进行了文献检索。
FUS患者的房水样本对RV呈特异性和敏感性免疫反应。RV基因组的鉴定证实了一部分FUS患者存在眼内感染。流行病学研究结果进一步支持因果关系。RV相关葡萄膜炎的临床谱与FUS相似但不完全相同。FUS眼表现为CD8 + T细胞占优势，IFN-γ和IL-10水平较高。
RV是FUS的主要病因。基于细胞因子的研究结果反映了病毒病因和慢性低度炎症。RV相关的FUS代表先天性或获得性感染后眼内RV接种的常见途径。其他病因，包括单纯疱疹病毒（HSV）和巨细胞病毒（CMV），可能导致FUS。
