Inflammatory Eye Disease Clinic. Asociación para Evitar la Ceguera en México, Vicente Garcia Torres No. 46 Coyoacán, Mexico City, 04030, Mexico.
Asociación para Evitar la Ceguera en México, Vicente Garcia Torres No. 46, Coyoacan, Mexico City, 04030, Mexico.
BMC Ophthalmol. 2024 Jan 19;24(1):27. doi: 10.1186/s12886-024-03304-0.
BACKGROUND/AIMS: To simultaneously evaluate iris area (IA) and subfoveal choroidal thickness (SFCT) in eyes with Fuchs Uveitis Syndrome (FUS).
We prospectively recruited a case series of patients with FUS at our institution, simultaneously measuring IA with anterior segment spectral domain optical coherence tomography (SD-OCT) and SFCT with enhanced depth imaging optical coherence tomography (EDI-OCT). Iris images were analyzed by ImageJ software. We tested the differences in intereye IA and SFCT with the healthy eye (HE) using the Wilcoxon test, and clinical interpretation was controlled by intraclass correlation coefficient (ICC) between two masked specialists.
Sixteen patients with unilateral FUS were included. Six were female, and the age range was 37 to 67 (median age 48 years, IQR 41-60). ICC of 98.9%, with a lower confidence interval of 97%. Eyes with FUS had a significant thinning of the total iris median area (p < 0.002), restricted to the temporal and nasal areas compared to the HE (p < 0.01 and < 0.001, respectively). SFCT was also significantly thinner compared to the HE (p < 0.0001). A low correlation was found between iris and choroidal thinning in FUS eyes (r = 0.21; p = 0.4).
This study found reduced iris area and subfoveal choroidal thickness in eyes with FUS compared to the normal fellow eye.
背景/目的：同时评估 Fuchs 葡萄膜炎综合征（FUS）患者的虹膜面积（IA）和黄斑下脉络膜厚度（SFCT）。
我们前瞻性地在我院招募了一系列 FUS 患者病例，使用前节光谱域光学相干断层扫描（SD-OCT）同时测量 IA，使用增强深度成像光学相干断层扫描（EDI-OCT）测量 SFCT。使用 ImageJ 软件分析虹膜图像。我们使用 Wilcoxon 检验检验双眼 IA 和 SFCT 的差异，并用两位盲法专家的组内相关系数（ICC）来控制临床解释。
纳入 16 例单侧 FUS 患者，其中 6 例为女性，年龄 37 至 67 岁（中位年龄 48 岁，四分位距 41-60 岁）。ICC 为 98.9%，置信区间下限为 97%。与对侧正常眼（HE）相比，FUS 眼的总虹膜面积明显变薄（p<0.002），局限于颞侧和鼻侧（分别为 p<0.01 和 <0.001）。SFCT 也明显比 HE 薄（p<0.0001）。FUS 眼的虹膜和脉络膜变薄之间相关性较低（r=0.21；p=0.4）。
与对侧正常眼相比，FUS 眼的虹膜面积和黄斑下脉络膜厚度减小。
