Mirzoyan R S, Ganshina T S, Pukhalskaya T G, Volobueva T I, Vedernikov Y P, Dikova M, Nikolova M, Nikolov R
Pharmacological Research Institute of USSR Academy of Medical Sciences, Moscow.
Methods Find Exp Clin Pharmacol. 1989 Nov;11(11):671-6.
The effect of nicergoline on cerebral blood flow (CBF), cerebrovascular resistance, the constriction of cerebral vessels caused reflectorily or by 5-hydroxytryptamine (5-HT) and on the transport of 5-HT in rat brain synaptosomes was studied using different experimental models. Nicergoline reduced cerebrovascular resistance in the carotid and vertebrobasilar system. The drug decreased carotid blood flow and local cortical CBF, preceded in some experiments by short-lasting CBF increase. Nicergoline almost completely inhibited brain vessels responses in the carotid and vertebrobasilar systems after tibial nerve stimulation. Simultaneously, inhibition of reflectory discharges of the sympathetic nerves was observed. Nicergoline showed an antiserotonin action by antagonizing the 5-HT effect on the cerebral circulation and inhibiting 5-HT-induced constriction of isolated rabbit basilar artery. The inhibition of uptake and enhancement of the release of 5-HT from brain synaptosomes indicates its ability to affect neuronal transmission in serotoninergic neurons. The effects of nicergoline are probably involved in the realization of its antimigraine action.
采用不同实验模型，研究了尼麦角林对大鼠脑血流量（CBF）、脑血管阻力、反射性或由5-羟色胺（5-HT）引起的脑血管收缩以及对大鼠脑突触体中5-HT转运的影响。尼麦角林降低了颈动脉和椎基底动脉系统的脑血管阻力。该药物减少了颈动脉血流量和局部皮质CBF，在某些实验中，之前会有短暂的CBF增加。尼麦角林在胫神经刺激后几乎完全抑制了颈动脉和椎基底动脉系统中的脑血管反应。同时，观察到交感神经反射性放电受到抑制。尼麦角林通过拮抗5-HT对脑循环的作用并抑制5-HT诱导的离体兔基底动脉收缩，表现出抗血清素作用。对脑突触体中5-HT摄取的抑制和释放的增强表明其能够影响5-羟色胺能神经元中的神经元传递。尼麦角林的作用可能与其抗偏头痛作用的实现有关。
