多西他赛每周给药方案治疗局部晚期心脏血管肉瘤的疗效
Efficacy of weekly docetaxel in locally advanced cardiac angiosarcoma.
作者信息
Minichillo Santino, Pantaleo Maria Abbondanza, Nannini Margherita, Coccolo Fabio, Gatto Lidia, Biasco Guido, Brandi Giovanni
机构信息
Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy.
"Giorgio Prodi" Cancer Research Center, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy.
出版信息
BMC Res Notes. 2015 Jul 30;8:325. doi: 10.1186/s13104-015-1296-4.
BACKGROUND
Primary cardiac angiosarcoma is extremely aggressive; however, it is often misdiagnosed because of its rarity. For locally advanced tumors, doxorubicin-based chemotherapy regimens are the standard of treatment, even if the gain in term of progression-free survival is limited and is no longer than 5 months.
CASE PRESENTATION
We report the case of a Caucasian 23-year-old man with locally advanced cardiac angiosarcoma who underwent radical surgical resection after a prolonged response to weekly docetaxel and complementary radiotherapy.
CONCLUSION
Combined treatment with weekly docetaxel and radiotherapy may be a valid alternative for the treatment of locally advanced cardiac angiosarcoma; the combination can lead to radical surgical resections, avoiding the cumulative cardiotoxicity of antracycline-based regimens.
背景
原发性心脏血管肉瘤极具侵袭性；然而，由于其罕见性，常被误诊。对于局部晚期肿瘤，基于阿霉素的化疗方案是治疗标准，即便无进展生存期的获益有限且不超过5个月。
病例报告
我们报告一例23岁白种男性局部晚期心脏血管肉瘤病例，该患者在对每周一次的多西他赛及辅助放疗有长期反应后接受了根治性手术切除。
结论
每周一次多西他赛与放疗联合治疗可能是局部晚期心脏血管肉瘤治疗的有效替代方案；该联合治疗可实现根治性手术切除，避免基于蒽环类药物方案的累积心脏毒性。
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