Haehner Antje, Habersack Angela, Wienecke Miriam, Storch Alexander, Reichmann Heinz, Hummel Thomas
Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, 01307, Dresden, Germany.
Department of Neurology, TU Dresden, Dresden, Germany.
J Neural Transm (Vienna). 2015 Nov;122(11):1541-6. doi: 10.1007/s00702-015-1433-1. Epub 2015 Jul 30.
The effects of rasagiline on olfaction in animal studies are convincing. However, apart from various anecdotal patient reports, they could not be reproduced in prospective studies in humans. Cross-sectional data of large patient groups are still missing. The aim of this study was therefore to determine the olfactory function in a broad heterogeneous Parkinson's disease (PD) population with and without rasagiline intake. In this single-center, cross-sectional study 224 PD patients with and without rasagiline (1 mg/day) participated. Seventy-four of them received rasagiline as mono, or adjunct therapy. One-hundred fifty patients were untreated or received PD medication other than rasagiline. Comprehensive olfactory testing was performed for phenyl-ethyl alcohol odor thresholds, odor discrimination, and odor identification. Olfactory function did not differ between the two treatment groups with disease duration up to 29 years. Rasagiline-treated patients with disease duration of less than 8 years, however, presented with significant better odor discrimination abilities compared to PD patients without rasagiline treatment. This effect was no longer evident in patients with longer disease duration and proofed to be independent of age, sex, and medication. Our results may suggest that rasagiline treatment has a positive effect on the processing of olfactory information in early PD.
雷沙吉兰在动物研究中对嗅觉的影响是令人信服的。然而，除了各种患者的轶事报告外，这些影响在人类前瞻性研究中未能得到重现。大型患者群体的横断面数据仍然缺失。因此，本研究的目的是确定在广泛的、异质性的帕金森病（PD）患者群体中，服用和未服用雷沙吉兰时的嗅觉功能。在这项单中心横断面研究中，224名服用和未服用雷沙吉兰（1毫克/天）的PD患者参与其中。其中74人接受雷沙吉兰作为单一疗法或辅助疗法。150名患者未接受治疗或接受除雷沙吉兰之外的PD药物治疗。对苯乙醇气味阈值、气味辨别和气味识别进行了全面的嗅觉测试。在疾病持续时间长达29年的两个治疗组之间，嗅觉功能没有差异。然而，与未接受雷沙吉兰治疗的PD患者相比，疾病持续时间小于8年的接受雷沙吉兰治疗的患者表现出明显更好的气味辨别能力。在疾病持续时间较长的患者中，这种效果不再明显，并且被证明与年龄、性别和药物治疗无关。我们的结果可能表明，雷沙吉兰治疗对早期PD患者嗅觉信息的处理有积极作用。
