Daraseliia G Ia, Khachapuridze D O, Gagelidze N A, Amiranashvili L L
Mikrobiologiia. 1989 Jul-Aug;58(4):596-601.
The kinetics of growth, development, carotenogenesis and changes in the composition of the reaction medium were studied in the course of Mycobacterium rubrum batch cultivation in synthetic and complex media. The culture growth was found to be composed of five phases in the synthetic medium and of four phases in the complex medium. When the culture was grown in the synthetic medium, the phenomenon of distinct diauxy was recorded by changes in the specific growth rate as well as the economic and metabolic coefficients. These growth changes were shown to be associated with the fact that the culture started to assimilate sucrose instead of glucose at the subsequent growth phases, and carbotenogenesis was found to be uncoupled with the period of active biomass and protein synthesis.
在合成培养基和复合培养基中分批培养红色分枝杆菌的过程中，研究了其生长、发育、类胡萝卜素生成动力学以及反应培养基成分的变化。结果发现，在合成培养基中培养时，培养物生长由五个阶段组成；在复合培养基中培养时，由四个阶段组成。当培养物在合成培养基中生长时，通过比生长速率以及经济和代谢系数的变化记录到了明显的二次生长现象。这些生长变化表明，培养物在随后的生长阶段开始同化蔗糖而非葡萄糖，并且发现类胡萝卜素生成与活跃生物量和蛋白质合成时期解偶联。
