Pritchett-Corning Kathleen R, Peery Harry E, Crossland Janet P, Wyatt Heather M, Stuart Marilyne, Mothersill Carmel E
Office of Animal Resources, Harvard University Faculty of Arts and Sciences, Cambridge, Massachusetts, USA; Charles River Laboratories, Wilmington, Massachusetts, USA.
Division of Reproductive Biology, Department of Obstetrics and Gynecology, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
J Am Assoc Lab Anim Sci. 2015 Jul;54(4):439-44.
Helicobacter species can be found in a wide variety of animals and remain common contaminants of laboratory rodents. Fostering of neonatal pups has been used to eliminate Helicobacter spp. from various laboratory rodents, including laboratory mice and gerbils. Deer mice (Peromyscus maniculatus) from a captive colony enzootic for at least one Helicobacter species were mated, and the pups produced were fostered on laboratory mice 24 h after birth. After 2 rounds of fostering, both foster dams and pups were free of Helicobacter spp. as determined by fecal PCR analysis. Removal of Helicobacter infection through neonatal fostering has not been described previously for Peromyscus maniculatus.
幽门螺杆菌可在多种动物中发现，并且仍然是实验室啮齿动物常见的污染物。新生幼崽的寄养已被用于清除包括实验室小鼠和沙鼠在内的各种实验室啮齿动物体内的幽门螺杆菌。来自至少感染一种幽门螺杆菌的圈养种群的鹿鼠（白足鼠）进行交配，所产幼崽在出生后24小时寄养在实验室小鼠身上。经过两轮寄养后，通过粪便PCR分析确定，寄养母鼠和幼崽均未感染幽门螺杆菌。此前尚未有关于通过新生幼崽寄养清除白足鼠幽门螺杆菌感染的描述。
