Nakashima Tomoki
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan./Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO), Japan.
Clin Calcium. 2015 Aug;25(8):1220-8.
Bone, which support motile organ and periodontal tissue, is renewing throughout our life. This restructuring process is called "bone remodeling" , and osteoclasts and osteoblasts play a crucial role in this process. Bone remodeling is important not only for normal bone mass and strength, but also for mineral homeostasis. Bone remodeling is stringently regulated by communication between bone component cells such as osteoclasts, osteoblasts and osteocytes. An imbalance of this process is often linked to various bone diseases. Alveolar bone remodeling is directly influenced by occlusal force from the teeth. Thus, the elucidation of the regulatory mechanisms involved in alveolar bone remodeling is critical for a deeper understanding of the maintenance of healthy tooth and dental disease.
支撑运动器官和牙周组织的骨骼在我们的一生中不断更新。这个重塑过程被称为“骨重塑”，破骨细胞和成骨细胞在这个过程中起着至关重要的作用。骨重塑不仅对正常的骨量和强度很重要，而且对矿物质稳态也很重要。骨重塑受到破骨细胞、成骨细胞和骨细胞等骨组成细胞之间通讯的严格调控。这个过程的失衡通常与各种骨疾病有关。牙槽骨重塑直接受到牙齿咬合力的影响。因此，阐明牙槽骨重塑所涉及的调控机制对于更深入地理解健康牙齿的维持和牙齿疾病至关重要。
