成像肿瘤酸度：用于光声断层成像的低pH插入肽探针
Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography.
作者信息
Reshetnyak Yana K
机构信息
Division Biological and Medical Physics, Physics Department, University of Rhode Island, Kingston, Rhode Island.
出版信息
Clin Cancer Res. 2015 Oct 15;21(20):4502-4. doi: 10.1158/1078-0432.CCR-15-1502. Epub 2015 Jul 29.
Abstract
Optoacoustic tomography has been used for the detection of pancreatic ductal adenocarcinoma targeted by pH-low insertion peptide (pHLIP) conjugated to near-infrared fluorescent dye. It was proved that tumor targeting is pH dependent. The approach could have major implication for detection and monitoring of pancreatic and other cancers.
摘要
光声断层扫描已用于检测由与近红外荧光染料偶联的pH-低插入肽（pHLIP）靶向的胰腺导管腺癌。事实证明，肿瘤靶向作用是pH依赖性的。该方法可能对胰腺和其他癌症的检测及监测具有重要意义。
相似文献
1
Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography.成像肿瘤酸度：用于光声断层成像的低pH插入肽探针
Clin Cancer Res. 2015 Oct 15;21(20):4502-4. doi: 10.1158/1078-0432.CCR-15-1502. Epub 2015 Jul 29.
2
Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo.靶向胰腺腺癌中的酸度：多光谱光声断层扫描在体内检测pH值低的插入肽探针
Clin Cancer Res. 2015 Oct 15;21(20):4576-85. doi: 10.1158/1078-0432.CCR-15-0314. Epub 2015 Jun 29.
3
Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography.肿瘤特异性脂质体通过光声断层扫描改善了体内胰腺腺癌的检测。
J Nanobiotechnology. 2015 Dec 1;13:90. doi: 10.1186/s12951-015-0139-8.
4
Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1.使用 Syndecan-1 通过光声断层成像术检测到的原位胰腺肿瘤。
J Surg Res. 2015 Jan;193(1):246-54. doi: 10.1016/j.jss.2014.06.045. Epub 2014 Oct 13.
5
Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo.通过ICG pHLIP肽在体外对人膀胱尿路上皮癌进行靶向成像。
Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11829-11834. doi: 10.1073/pnas.1610472113. Epub 2016 Sep 29.
6
Early diagnosis of pancreatic adenocarcinoma: role of stroma, surface proteases, and glucose-homeostatic agents.早期胰腺癌诊断：基质、表面蛋白酶和糖稳态因子的作用。
Pancreas. 2012 Jul;41(5):663-70. doi: 10.1097/MPA.0b013e31823b5827.
7
Pharmacokinetic modeling reveals parameters that govern tumor targeting and delivery by a pH-Low Insertion Peptide (pHLIP).药代动力学模型揭示了 pH-低插入肽（pHLIP）靶向和递送至肿瘤的参数。
Proc Natl Acad Sci U S A. 2021 Jan 5;118(1). doi: 10.1073/pnas.2016605118. Epub 2020 Dec 21.
8
Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas.使用靶向正常胰腺的肽-纳米颗粒偶联物对胰腺癌进行成像。
Bioconjug Chem. 2006 Jul-Aug;17(4):905-11. doi: 10.1021/bc060035+.
9
Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo.一种在体内靶向肿瘤和其他酸性组织的膜肽的作用机制及用途。
Proc Natl Acad Sci U S A. 2007 May 8;104(19):7893-8. doi: 10.1073/pnas.0702439104. Epub 2007 May 1.
10
Biomarkers in pancreatic ductal adenocarcinoma.胰腺导管腺癌的生物标志物。
Clin Transl Oncol. 2017 Dec;19(12):1430-1437. doi: 10.1007/s12094-017-1691-5. Epub 2017 Jun 14.
引用本文的文献
1
Ultra-high sensitivity pH sensor based on vertical organic electrochemical transistors with extended gate.基于具有扩展栅极的垂直有机电化学晶体管的超高灵敏度pH传感器。
Mikrochim Acta. 2024 Jun 14;191(7):391. doi: 10.1007/s00604-024-06472-4.
2
pHLIP-fused PD-L1 engages avelumab to elicit NK cytotoxicity under acidic conditions.在酸性条件下，pHLIP融合的程序性死亡受体配体1（PD-L1）与阿维鲁单抗结合，引发自然杀伤细胞的细胞毒性。
Heliyon. 2024 May 3;10(9):e30551. doi: 10.1016/j.heliyon.2024.e30551. eCollection 2024 May 15.
3
Recent Advances in Imaging Agents Anchored with pH (Low) Insertion Peptides for Cancer Theranostics.基于 pH（低）插入肽的成像剂在癌症诊疗中的最新进展。
Molecules. 2023 Feb 26;28(5):2175. doi: 10.3390/molecules28052175.
4
Innovative Imaging Techniques Used to Evaluate Borderline-Resectable Pancreatic Adenocarcinoma.创新影像学技术用于评估边界可切除胰腺腺癌。
J Surg Res. 2023 Apr;284:42-53. doi: 10.1016/j.jss.2022.10.008. Epub 2022 Dec 17.
5
Nucleic acid-triggered tumoral immunity propagates pH-selective therapeutic antibodies through tumor-driven epitope spreading.核酸触发的肿瘤免疫通过肿瘤驱动的表位扩展将 pH 选择性治疗性抗体传播到肿瘤中。
Cancer Sci. 2023 Jan;114(1):321-338. doi: 10.1111/cas.15596. Epub 2022 Oct 17.
6
Multiplexed imaging in oncology.肿瘤学中的多重成像。
Nat Biomed Eng. 2022 May;6(5):527-540. doi: 10.1038/s41551-022-00891-5. Epub 2022 May 27.
7
Imidazole-Based pH-Sensitive Convertible Liposomes for Anticancer Drug Delivery.用于抗癌药物递送的基于咪唑的pH敏感可转换脂质体
Pharmaceuticals (Basel). 2022 Mar 3;15(3):306. doi: 10.3390/ph15030306.
8
Roles of key residues and lipid dynamics reveal pHLIP-membrane interactions at intermediate pH.关键残基和脂质动力学在揭示中间 pH 下 pHLIP 与膜的相互作用中的作用。
Biophys J. 2021 Nov 2;120(21):4649-4662. doi: 10.1016/j.bpj.2021.10.001. Epub 2021 Oct 6.
9
Toxic proteins application in cancer therapy.有毒蛋白在癌症治疗中的应用。
Mol Biol Rep. 2021 Apr;48(4):3827-3840. doi: 10.1007/s11033-021-06363-4. Epub 2021 Apr 25.
10
Extracellular Acidosis Promotes Metastatic Potency via Decrease of the Circadian Clock Gene in Breast Cancer.细胞外酸中毒通过降低乳腺癌中的昼夜节律钟基因促进转移能力。
Cells. 2020 Apr 16;9(4):989. doi: 10.3390/cells9040989.
本文引用的文献
1
Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo.靶向胰腺腺癌中的酸度：多光谱光声断层扫描在体内检测pH值低的插入肽探针
Clin Cancer Res. 2015 Oct 15;21(20):4576-85. doi: 10.1158/1078-0432.CCR-15-0314. Epub 2015 Jun 29.
2
Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.了解代谢型 PET 示踪剂在前列腺癌中的药理学特性。
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7254-9. doi: 10.1073/pnas.1405240111. Epub 2014 May 1.
3
Targeting diseased tissues by pHLIP insertion at low cell surface pH.通过在低细胞表面pH值下插入pHLIP靶向病变组织。
Front Physiol. 2014 Mar 13;5:97. doi: 10.3389/fphys.2014.00097. eCollection 2014.
4
Targeting pancreatic ductal adenocarcinoma acidic microenvironment.靶向胰腺导管腺癌酸性微环境。
Sci Rep. 2014 Mar 19;4:4410. doi: 10.1038/srep04410.
5
pH sensing and regulation in cancer.癌症中的pH传感与调节
Front Physiol. 2013 Dec 17;4:370. doi: 10.3389/fphys.2013.00370.
6
Family of pH (low) insertion peptides for tumor targeting.用于肿瘤靶向的 pH（低）插入肽家族。
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5834-9. doi: 10.1073/pnas.1303708110. Epub 2013 Mar 25.
7
Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation.高效（18）F 标记的大型 pHLIP 肽类似物及其生物学评价。
Bioconjug Chem. 2012 Aug 15;23(8):1557-66. doi: 10.1021/bc3000222. Epub 2012 Jul 30.
8
Adverse Cell Culture Conditions Mimicking the Tumor Microenvironment Upregulate ABCG2 to Mediate Multidrug Resistance and a More Malignant Phenotype.模拟肿瘤微环境的不良细胞培养条件上调ABCG2以介导多药耐药性和更恶性的表型。
ISRN Oncol. 2012;2012:746025. doi: 10.5402/2012/746025. Epub 2012 Jun 14.
9
Volumetric real-time multispectral optoacoustic tomography of biomarkers.容积实时多光谱光声断层成像生物标志物。
Nat Protoc. 2011 Jul 7;6(8):1121-9. doi: 10.1038/nprot.2011.351.
10
Imaging pH and metastasis.成像 pH 值与转移。
NMR Biomed. 2011 Jul;24(6):582-91. doi: 10.1002/nbm.1644. Epub 2011 Mar 8.
Zotero 插件