Juty N, Ali R, Glont M, Keating S, Rodriguez N, Swat M J, Wimalaratne S M, Hermjakob H, Le Novère N, Laibe C, Chelliah V
European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus Hinxton, Cambridge, UK.
Babraham Institute, Babraham Research Campus Cambridge, UK.
CPT Pharmacometrics Syst Pharmacol. 2015 Feb;4(2):e3. doi: 10.1002/psp4.3. Epub 2015 Feb 26.
BioModels is a reference repository hosting mathematical models that describe the dynamic interactions of biological components at various scales. The resource provides access to over 1,200 models described in literature and over 140,000 models automatically generated from pathway resources. Most model components are cross-linked with external resources to facilitate interoperability. A large proportion of models are manually curated to ensure reproducibility of simulation results. This tutorial presents BioModels' content, features, functionality, and usage.
生物模型库是一个参考资源库,其中存放着描述生物组件在不同尺度下动态相互作用的数学模型。该资源库提供了对文献中描述的1200多个模型以及从通路资源自动生成的140000多个模型的访问。大多数模型组件与外部资源交联,以促进互操作性。很大一部分模型经过人工整理,以确保模拟结果的可重复性。本教程介绍了生物模型库的内容、特点、功能和用法。