Sinnett Philip Marcus, Carr Branden, Cook Gregory, Mucklerath Halie, Varney Laura, Weiher Matt, Yerokhin Vadim, Vassar Matt
Oklahoma State University Center for Health Sciences, Tulsa, OK, United States of America.
PLoS One. 2015 Jul 30;10(7):e0134596. doi: 10.1371/journal.pone.0134596. eCollection 2015.
We examined the use of clinical trials registries in published systematic reviews and meta-analyses from clinical neurology. A review of publications between January 1, 2008 and December 31, 2014 from five neuroscience journals (Annals of Neurology, Brain, Lancet Neurology, Neurology, and The Neuroscientist) was performed to identify eligible systematic reviews. The systematic reviews comprising the final sample were independently appraised to determine if clinical trials registries had been included as part of the search process. Studies acknowledging the use of a trials registry were further examined to determine whether trial data had been incorporated into the analysis. The initial search yielded 194 studies, of which 78 systematic reviews met the selection criteria. Of those, five acknowledged the use of a specific clinical trials registry: four reviewed unpublished trial data and two incorporated unpublished trial data into their results. Based on our sample of systematic reviews, there was no increase in the use of trials registries in systematic review searches over time. Few systematic reviews published in clinical neurology journals included data from relevant clinical trials registries.
我们研究了临床试验注册库在已发表的临床神经学系统评价和荟萃分析中的使用情况。对2008年1月1日至2014年12月31日期间来自五本神经科学期刊（《神经病学年鉴》《大脑》《柳叶刀神经病学》《神经病学》和《神经科学家》）的出版物进行了回顾，以确定符合条件的系统评价。对构成最终样本的系统评价进行独立评估，以确定临床试验注册库是否作为检索过程的一部分被纳入。对承认使用试验注册库的研究进一步检查，以确定试验数据是否已纳入分析。初步检索产生了194项研究，其中78项系统评价符合入选标准。其中，五项承认使用了特定的临床试验注册库：四项审查了未发表的试验数据，两项将未发表的试验数据纳入了结果。基于我们的系统评价样本，随着时间的推移，系统评价检索中试验注册库的使用没有增加。临床神经学杂志发表的系统评价很少包括来自相关临床试验注册库的数据。
