Molokovskiĭ D S, Davydov V V, Tiulenev V V
Probl Endokrinol (Mosk). 1989 Nov-Dec;35(6):82-7.
Experiments on mice and rats with alloxan diabetes were conducted for comparative assessment of the effectiveness of therapeutic use of adaptogenic plant pharmaceuticals as well as some other commonly used plant drugs. Of marked antidiabetic properties were root and leaf ginseng tincture (LGT), Echinopanax tincture, extracts of Eleutherococcus, Rhodiola (ER) and Leuzia which decreased the blood level of glucose in a CTT (5 g h of glucose per I kg of the animal body mass) from 17.15 to 11.19, 11.50, 12.72, 11.69, 13.47 mmol/l and increased the alloxan-reduced level of liver glycogen by 50-80% (P less than 0.05). Aralia and Schizandra tinctures for this diabetic model were ineffective. Yarrow, everlastings and birch leaf tea also possessed marked hypoglycemic and glycogen sparing properties. The most effective experimentally plant adaptogens LGT and ER increased the blood level of insulin in alloxan diabetic rats in a GTT from 16.75 up to 44.42, 35.31 microU/ml and decreased the level of glucagon from 495 to 195 and 138 pg/ml, respectively. The authors discussed mechanisms of antidiabetic, insulinotropic and hypoglucagonemic action of the effective plant pharmaceuticals and the prospects of their use in multimodality therapy of diabetes mellitus of type I.
对用四氧嘧啶诱导糖尿病的小鼠和大鼠进行了实验，以比较评估适应原性植物药物以及其他一些常用植物药的治疗效果。具有显著抗糖尿病特性的有根及叶人参酊（LGT）、刺五加酊、刺蒺藜提取物、红景天（ER）和列兹亚，它们可使口服葡萄糖耐量试验（CTT，每千克动物体重给予5克葡萄糖）中的血糖水平从17.15降至11.19、11.50、12.72、11.69、13.47毫摩尔/升，并使四氧嘧啶降低的肝糖原水平提高50 - 80%（P小于0.05）。对于该糖尿病模型，刺楸和五味子酊无效。蓍草、蜡菊和桦树叶茶也具有显著的降血糖和糖原节省特性。实验中最有效的植物适应原LGT和ER可使四氧嘧啶糖尿病大鼠口服葡萄糖耐量试验（GTT）中的胰岛素血水平从16.75分别升至44.42、35.31微单位/毫升，并使胰高血糖素水平分别从495降至195和138皮克/毫升。作者讨论了有效植物药物的抗糖尿病、促胰岛素分泌和降胰高血糖素作用机制以及它们在I型糖尿病多模式治疗中的应用前景。
