[Comparative evaluation of the hypoglycemic activity of the vegetal complex of Phaseolus vulgaris and chlorpropamide in experimental diabetes].

Experiments on rabbits with alloxan diabetes showed that the plant complex (PC) reduced the level of glycemia after single administration for 6-8 h by 27-32%. A similar effect was demonstrated with chlorpropamide. However the PC produced a longer hypoglycemic effect. In course treatment the PC returned the blood level of glucose (5.14 +/- 0.62 mmol/l) to normal on the 11th day whereas with chlorpropamide this indicator was almost normal (6.6 +/- 1.1 mmol/l) on the 15th day only. A rapid decrease in the blood glucose concentration caused by the PC was observed in AIS induced hyperglycemia. The PC demonstrated its sugar reducing action by extrapancreatic means.