Sandhofer M, Fritz J, Altmann H
Aktuelle Gerontol. 1977 Dec;7(12):645-51.
Scleroderma with its different manifestations is mainly a disease of connective tissue and of vascular system. Next the alteration to collagen, which is demonstrable in lesions by decrease of embryonale collagen type III, there are also humoral and cellular phenomens of autoimmunity. In more than 70% of our patients we found antinuclear antibodies, and in most of them, we found with the leukocytemigration--inhibition-test cellular immunphenomenons to RNA, collagen and muscle. There is a small connection between ageing and immunological defense and repair, accordingly of immunocytes and fibroblasts. Further more precise characterization of this cell-compartments under the aspect of a premature ageing could bring a new understanding in the largely unknown etiopathogenese of scleroderma.
硬皮病有不同的表现形式，主要是一种结缔组织和血管系统疾病。其次，在病变中可通过胚胎型III型胶原蛋白减少来证明的胶原蛋白改变，也存在自身免疫的体液和细胞现象。在我们70%以上的患者中发现了抗核抗体，并且在大多数患者中，我们通过白细胞迁移抑制试验发现了针对RNA、胶原蛋白和肌肉的细胞免疫现象。衰老与免疫防御和修复之间存在微弱联系，免疫细胞和成纤维细胞也是如此。在早衰方面对这些细胞区室进行更精确的表征，可能会为硬皮病在很大程度上未知的病因发病机制带来新的认识。
