Barr-Gillespie Peter-G
Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, OR 97239
Mol Biol Cell. 2015 Aug 1;26(15):2727-32. doi: 10.1091/mbc.E14-04-0940.
The hair bundle--the sensory organelle of inner-ear hair cells of vertebrates--exemplifies the ability of a cell to assemble complex, elegant structures. Proper construction of the bundle is required for proper mechanotransduction in response to external forces and to transmit information about sound and movement. Bundles contain tightly controlled numbers of actin-filled stereocilia, which are arranged in defined rows of precise heights. Indeed, many deafness mutations that disable hair-cell cytoskeletal proteins also disrupt bundles. Bundle assembly is a tractable problem in molecular and cellular systems biology; the sequence of structural changes in stereocilia is known, and a modest number of proteins may be involved.
毛束——脊椎动物内耳毛细胞的感觉细胞器——体现了细胞组装复杂而精致结构的能力。毛束的正确构建是对外力进行适当机械转导以及传递声音和运动信息所必需的。毛束包含数量受到严格控制的充满肌动蛋白的静纤毛，这些静纤毛按精确高度排列成特定的排。事实上，许多使毛细胞细胞骨架蛋白失活的耳聋突变也会破坏毛束。在分子和细胞系统生物学中，毛束组装是一个易于处理的问题；静纤毛结构变化的顺序是已知的，并且可能涉及数量不多的蛋白质。
