Petruzzelli Maria Giuseppina, Margari Lucia, Craig Francesco, Campa Maria Gloria, Martinelli Domenico, Pastore Adriana, Simone Marta, Margari Francesco
Child and Adolescence Neuropsychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University "Aldo Moro" of Bari, Foggia, Italy.
Department of Medical and Surgical Sciences; University of Foggia, Foggia, Italy.
Neuropsychiatr Dis Treat. 2015 Jul 20;11:1793-8. doi: 10.2147/NDT.S83904. eCollection 2015.
The aim of this study was to assess the association between the clinical and neurobiological markers of neurodevelopmental impairments and early-onset schizophrenia spectrum psychosis.
A sample of 36 patients with early-onset schizophrenia spectrum psychosis was compared to a control sample of 36 patients with migraine. We assessed early childhood neurodevelopmental milestones using a modified version of the General Developmental Scale, general intellectual ability using the Wechsler Intelligence Scale for Children-Revised or Leiter International Performance Scale-Revised for patients with speech and language abnormalities, and neurological soft signs with specific regard to subtle motor impairment.
Subjects with early-onset psychosis had a higher rate of impaired social development (P=0.001), learning difficulties (P=0.04), enuresis (P=0.0008), a lower intelligence quotient (P<0.001), and subtle motor impairments (P=0.005) than control subjects.
We suggest that neurodevelopment in early-onset psychosis is characterized by a global impairment of functional and adaptive skills that manifests from early childhood, rather than a delay or limitation in language and motor development. The current evidence is based on a small sample and should be investigated in larger samples in future research.
本研究旨在评估神经发育障碍的临床和神经生物学标志物与早发性精神分裂症谱系精神病之间的关联。
将36例早发性精神分裂症谱系精神病患者的样本与36例偏头痛患者的对照样本进行比较。我们使用改良版的一般发育量表评估幼儿期神经发育里程碑，对于有言语和语言异常的患者，使用韦氏儿童智力量表修订版或莱特国际操作量表修订版评估一般智力能力，并特别关注细微运动障碍来评估神经学软体征。
与对照受试者相比，早发性精神病患者的社会发育受损率更高（P = 0.001）、学习困难（P = 0.04）、遗尿（P = 0.0008）、智商较低（P < 0.001）以及细微运动障碍（P = 0.005）。
我们认为，早发性精神病中的神经发育特征是从幼儿期就出现的功能和适应技能的全面受损，而不是语言和运动发育的延迟或受限。目前的证据基于小样本，未来研究应在更大样本中进行调查。
