丁螺环酮对应激和非应激大鼠血浆儿茶酚胺、心率及血压的影响。

Effects of buspirone on plasma catecholamines, heart rate, and blood pressure in stressed and nonstressed rats.

作者信息

Taylor J, Harris N, Krieman M, Vogel W H

机构信息

Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.

出版信息

Pharmacol Biochem Behav. 1989 Oct;34(2):349-53. doi: 10.1016/0091-3057(89)90325-0.

DOI:10.1016/0091-3057(89)90325-0

PMID:2622992

Abstract

The influence of buspirone upon plasma catecholamine levels, heart rate, and mean arterial blood pressure was studied in stressed and nonstressed rats. Measures were obtained directly via indwelling aortic catheters. Drug or vehicle were given acutely (10 mg/kg, IP) or twice a day for 10 days (10 mg and 20 mg/kg, SC). In nonstressed rats, a single dose of buspirone increased markedly plasma norepinephrine and epinephrine levels and decreased significantly heart rate with no effect on blood pressure. During stress, stress-induced increases in catecholamine levels were further elevated by the drug, whereas stress-induced increases of heart rate and mean arterial blood pressure were reduced. In chronically-pretreated rats, the effects of buspirone were similar to those observed after an acute injection. These effects of buspirone on plasma catecholamines are very different from those seen with other anxiolytics, whereas effects on heart rate and blood pressure are more similar.

摘要

研究了丁螺环酮对应激和非应激大鼠血浆儿茶酚胺水平、心率和平均动脉血压的影响。通过留置主动脉导管直接获取测量数据。药物或赋形剂急性给药（10mg/kg，腹腔注射）或每天两次，连续10天（10mg和20mg/kg，皮下注射）。在非应激大鼠中，单剂量丁螺环酮显著增加血浆去甲肾上腺素和肾上腺素水平，并显著降低心率，对血压无影响。在应激期间，药物进一步提高了应激诱导的儿茶酚胺水平升高，而应激诱导的心率和平均动脉血压升高则降低。在长期预处理的大鼠中，丁螺环酮的作用与急性注射后观察到的作用相似。丁螺环酮对血浆儿茶酚胺的这些作用与其他抗焦虑药非常不同，而对心率和血压的作用则更相似。