Institut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin, 14195 Berlin, Germany.
J Immunol Res. 2015;2015:743169. doi: 10.1155/2015/743169. Epub 2015 Jul 2.
Dendritic cells (DC) are professional antigen presenting cells and link the innate and adaptive immune system. During steady state immune surveillance in skin, DC act as sentinels against commensals and invading pathogens. Under pathological skin conditions, inflammatory cytokines, secreted by surrounding keratinocytes, dermal fibroblasts, and immune cells, influence the activation and maturation of different DC populations including Langerhans cells (LC) and dermal DC. In this review we address critical differences in human DC subtypes during inflammatory settings compared to steady state. We also highlight the functional characteristics of human DC subsets in inflammatory skin environments and skin diseases including psoriasis and atopic dermatitis. Understanding the complex immunoregulatory role of distinct DC subsets in inflamed human skin will be a key element in developing novel strategies in anti-inflammatory therapy.
树突状细胞 (DC) 是专业的抗原呈递细胞，连接先天免疫系统和适应性免疫系统。在皮肤的稳态免疫监视中，DC 作为对抗共生菌和入侵病原体的哨兵。在病理性皮肤条件下，周围角质形成细胞、真皮成纤维细胞和免疫细胞分泌的炎症细胞因子，影响不同 DC 群体（包括朗格汉斯细胞 (LC) 和真皮 DC）的激活和成熟。在这篇综述中，我们比较了稳态和炎症状态下人类 DC 亚型的关键差异。我们还强调了人类 DC 亚群在炎症性皮肤环境和疾病中的功能特征，包括银屑病和特应性皮炎。了解不同 DC 亚群在炎症性人皮肤中的复杂免疫调节作用，将是开发抗炎治疗新策略的关键因素。
