Gandhi Manisha, Devaraj Sridevi, Sangi-Haghpeykar Haleh, Mastrobattista Joan
Baylor College of Medicine, Department of Obstetrics and Gynecology, USA.
Baylor College of Medicine, Department of Pathology, USA.
J Reprod Immunol. 2015 Nov;112:34-7. doi: 10.1016/j.jri.2015.06.003. Epub 2015 Jun 27.
The objective was to determine if there is an association between maternal body mass index (BMI) and maternal and neonatal pertussis antibody concentrations following vaccination. This is a nested cohort study of 123 women who received the Tdap vaccine during pregnancy. Women were stratified by BMI into three groups--normal, overweight, and obese, based on first trimester or pre-pregnancy BMI. Maternal and umbilical cord serum samples were tested for post-vaccination pertussis IgG antibody. The mean maternal pertussis antibody concentration was 167.5 U/mL for normal BMI (n=29), 169.8 U/mL for overweight BMI (n=54), and 175.5 U/mL for the obese BMI groups (n=40). The mean fetal pertussis antibody concentrations were 182.3 U/mL, 191.4 U/mL, and 197.7 U/mL for these groups respectively. Seroprotection was achieved in 89.7% of neonates (26/29) in the normal BMI group, 87.0% (47/54) in the overweight BMI group, and 97.5% (39/40) in the obese BMI group. None of these differences reached statistical significance. Maternal BMI does not affect the maternal or neonatal pertussis antibody response to the Tdap vaccine in women who receive the vaccine in pregnancy. Maternal BMI is unlikely to affect the neonatal protective effects of a standard dose of Tdap vaccine in pregnancy. PRéCIS: Maternal and umbilical cord antibody response to the pertussis vaccine is not affected by maternal body mass index.
目的是确定孕期接种疫苗后，母亲体重指数（BMI）与母亲及新生儿百日咳抗体浓度之间是否存在关联。这是一项对123名在孕期接种破伤风类毒素、白喉、百日咳疫苗（Tdap）的女性进行的巢式队列研究。根据孕早期或孕前BMI，将女性按BMI分为三组——正常、超重和肥胖。检测母亲和脐带血清样本接种疫苗后的百日咳IgG抗体。正常BMI组（n = 29）母亲百日咳抗体平均浓度为167.5 U/mL，超重BMI组（n = 54）为169.8 U/mL，肥胖BMI组（n = 40）为175.5 U/mL。这些组胎儿百日咳抗体平均浓度分别为182.3 U/mL、191.4 U/mL和197.7 U/mL。正常BMI组89.7%（26/29）的新生儿、超重BMI组87.0%（47/54）的新生儿和肥胖BMI组97.5%（39/40）的新生儿实现了血清保护。这些差异均未达到统计学显著性。母亲BMI不影响孕期接种Tdap疫苗的女性的母亲或新生儿百日咳抗体反应。母亲BMI不太可能影响孕期标准剂量Tdap疫苗对新生儿的保护作用。摘要：母亲和脐带对百日咳疫苗的抗体反应不受母亲体重指数的影响。
