Charles University in Prague - 3rd Faculty of Medicine,Ruská 87,100 00 Prague 10,Czech Republic.
Alexander Dubček University of Trenčín, Faculty of Healthcare,Študentská 2, 911 50 Trenčín,Slovakia.
Epidemiol Infect. 2018 Dec;146(16):2079-2085. doi: 10.1017/S095026881800242X. Epub 2018 Aug 23.
An evaluation of the relationship between predictors and immune response was conducted using data obtained from a clinical trial in 200 Czech healthy adults aged 24-65 years receiving a booster dose of a monovalent tetanus vaccine in 2017. The response was determined from ELISA antibody concentrations of paired sera obtained before and 4 weeks after the immunisation. While all subjects with initial antibody levels 2.2 IU/ml. The immune response was not affected by sex, age, tetanus vaccine type, concomitant medication, related adverse events or post-vaccination period since there were no significant differences in geometric mean concentrations or seroconversion rates. The seroconversion rate of 56% in smokers was significantly lower than that of 73% achieved in non-smokers. Although the seroconversion rates did not differ between individuals with normal or higher body weight, the adjusted odds ratio (1.3; 95% Cl 1.08-1.60) revealed a positive correlation between seroconversion rate and body mass index (BMI). Although the vaccine-induced response was influenced by pre-vaccination antibody levels, smoking or BMI, the booster immunisation against tetanus produced a sufficient response regardless the predictors.
对 200 名 24-65 岁的捷克健康成年人进行了一项评估，这些成年人在 2017 年接受了破伤风单价疫苗的加强剂量，该研究是在一项临床试验中获得的数据。免疫反应通过 ELISA 抗体浓度来确定，使用的是免疫前和免疫后 4 周采集的配对血清。尽管所有初始抗体水平为 2.2IU/ml 的受试者。免疫反应不受性别、年龄、破伤风疫苗类型、伴随用药、相关不良事件或疫苗接种后时期的影响，因为几何均数浓度或血清转化率没有显著差异。吸烟者的血清转化率为 56%，明显低于非吸烟者的 73%。虽然体重正常或更高的个体之间的血清转化率没有差异，但调整后的优势比（1.3；95%Cl1.08-1.60）显示血清转化率与体重指数（BMI）之间存在正相关。尽管疫苗诱导的反应受到疫苗前抗体水平、吸烟或 BMI 的影响，但破伤风加强免疫产生了足够的反应，无论预测因素如何。
