Fernánez Martín J L, Macho M, Gómez Granda E, Díaz López B, Sanz Medel A, Cannata J B
Rev Clin Esp. 1989 Nov;185(8):388-90.
The first cases of aluminium (Al) toxicity were reported in metal workers with apparent normal renal function. Although safety in industry has had a great improvement over the last decades, it is reasonable to think that Al workers might have a higher daily Al exposure than normal population. Therefore the aim of this study was to investigate the serum Al levels in volunteers with normal renal function, having different jobs, including people working in the main Al factory in our area. There were no significant differences in serum Al values among people working in the Al factory or in other jobs, likewise there were no differences regarding: sex, alcohol consumption, smoking habits, etc. By contrast, as we expected, urinary Al excretion was higher (p less than 0.005) in Al workers. There was a significant serum Al increase proportional to the increase of age (p less than 0.01). The known decline of renal function observed with the increasing of age and therefore the likely decrease in Al clearance, could be responsible for the serum Al increase.
首例铝（Al）中毒病例是在肾功能明显正常的金属工人中报告的。尽管在过去几十年里工业安全有了很大改善，但有理由认为铝作业工人的每日铝暴露量可能高于正常人群。因此，本研究的目的是调查肾功能正常、从事不同工作的志愿者的血清铝水平，包括我们地区主要铝厂的工人。铝厂工人与从事其他工作的人之间血清铝值无显著差异，在性别、饮酒、吸烟习惯等方面同样无差异。相比之下，正如我们所预期的，铝作业工人的尿铝排泄量更高（p<0.005）。血清铝随年龄增长显著升高（p<0.01）。随着年龄增长观察到的已知肾功能下降以及因此可能的铝清除率降低，可能是血清铝升高的原因。
