Olaizola Ottonello I, Serrano Arias M, Vizoso Piñeiro F, Rodrigo Saez L, García Morán M, Cannata Andía J B
Unidad de Investigación Metabolismo Oseo y Mineral, Hospital General de Asturias, Oviedo, España.
Rev Clin Esp. 1991 May;188(9):442-5.
Aluminium is a toxic metal of known importance in patients with chronic renal failure on hemodialysis, with a gastrointestinal absorption modulated by several factors including gastric pH which modifies the solubility of Aluminium hydroxide and can increase its absorption. We studied twenty six patients with normal renal function: control (n = 13); presurgery (n = 8); postsurgery (n = 5) by an aluminium hydroxide absorption test (30 mg/kg); serum and urinary aluminium was determined as well as gastric pH and hematologic parameters at different time periods. It was observed that presurgery ulcer patients (pH mean = 2.09) increased serum and urine aluminium levels as well as aluminium/creatinine ratio in urine after the test, opposite to what occurs in the postsurgery group (pH mean = 5.78) in which such parameters were not significantly modified. No differences were found in hematological parameters between the two groups. Our results indicate that acid gastric pH seems to be a factor capable of increasing gastrointestinal absorption of aluminium hydroxide since its solubility and thus its disponibility is increased, and make a point on the risk of a prolonged administration of antacids containing aluminium in patients with normal renal function.
铝是一种有毒金属，在接受血液透析的慢性肾衰竭患者中具有已知的重要性，其胃肠道吸收受多种因素调节，包括胃pH值，胃pH值会改变氢氧化铝的溶解度并可能增加其吸收。我们通过氢氧化铝吸收试验（30mg/kg）研究了26例肾功能正常的患者：对照组（n = 13）；术前组（n = 8）；术后组（n = 5），并在不同时间段测定了血清和尿铝、胃pH值以及血液学参数。观察到术前溃疡患者（平均pH = 2.09）在试验后血清和尿铝水平以及尿铝/肌酐比值升高，这与术后组（平均pH = 5.78）的情况相反，术后组这些参数未发生显著改变。两组血液学参数无差异。我们的结果表明，胃酸pH值似乎是能够增加氢氧化铝胃肠道吸收的一个因素，因为其溶解度以及可用性增加，并指出了肾功能正常的患者长期服用含铝抗酸剂的风险。
