Nagiel Aaron, Sadda Srinivas R, Schwartz Steven D, Sarraf David
*Division of Retinal Disorders and Ophthalmic Genetics, Stein Eye Institute, Los Angeles, California; †Doheny Eye Institute, Los Angeles, California; and ‡Division of Retina, Stein Eye Institute, University of California Los Angeles Geffen School of Medicine, Los Angeles, California.
Retin Cases Brief Rep. 2015 Fall;9(4):269-72. doi: 10.1097/ICB.0000000000000184.
To describe the use of half-dose anti-vascular endothelial growth factor therapy in a patient with giant pigment epithelial detachments.
Observational case report. A 76-year-old woman with neovascular age-related macular degeneration presented with massive bilateral pigment epithelial detachments measuring over 1000 μm in height. Her right eye was treated with standard-dose aflibercept, which led to two large retinal pigment epithelium tears. Treatment of the left eye with half-dose aflibercept led to complete resolution of the detachment without tear formation.
Half-dose anti-vascular endothelial growth factor therapy resulted in resolution of a giant pigment epithelial detachment ∼1500 μm in maximal height and 10 mm in diameter.
Reduced-dose anti-vascular endothelial growth factor therapy may be considered as a treatment option for very large pigment epithelial detachments at high risk for retinal pigment epithelium tear formation.
描述半剂量抗血管内皮生长因子疗法在一名巨大色素上皮脱离患者中的应用。
观察性病例报告。一名患有新生血管性年龄相关性黄斑变性的76岁女性，出现双侧巨大色素上皮脱离，高度超过1000μm。她的右眼接受了标准剂量阿柏西普治疗，导致两处大的视网膜色素上皮撕裂。左眼采用半剂量阿柏西普治疗，脱离完全消退且未形成撕裂。
半剂量抗血管内皮生长因子疗法使最大高度约1500μm、直径10mm的巨大色素上皮脱离消退。
对于视网膜色素上皮撕裂形成风险高的非常大的色素上皮脱离，可考虑采用减量抗血管内皮生长因子疗法作为一种治疗选择。
