Tran Thi Ha Chau, Dumas Stéphane, Coscas Florence
Ophthalmology Department, Lille Catholic Hospitals, Lille Catholic University, Lille, France.
Clinique de la Louvière, Lille, France.
J Ophthalmol. 2017;2017:8984313. doi: 10.1155/2017/8984313. Epub 2017 Sep 13.
To evaluate the response of intravitreal aflibercept injection (IAI) in eyes with detachment of retinal pigment epithelium (DEP) secondary to nAMD refractory to monthly ranibizumab.
This is a retrospective, multicenter study. All patients received 3 IAI then treated as needed every 4 weeks for 12 months. During the second year, the eyes were treated with a treat- and-extend regimen.
Forty-four eyes were included. Best-corrected visual acuity improved significantly after the loading phase (3.1 ± 6.4 letters) and at 6 months (2.8 ± 6.4 letters), but change was not significant at 1 year and 2 years. The height of the DEP was significantly decreased at 3 months and 6 months, but the difference did not reach statistical difference at 1 and 2 years. Rate of eyes with complete resolution of exudation was 59% after the loading phase and 34.3% at 2 years. Mean interval of anti-VEGF injection was extended from 31 ± 2.6 days to 61 ± 5 days after conversion.
Aflibercept intravitreal injection in patients with fibrovascular DEP due to nAMD who respond poorly to monthly ranibizumab led to short-term functional and anatomical improvement. Reduction of intravitreal injection frequency was obtained until 2 years of follow-up.
评估玻璃体内注射阿柏西普（IAI）对继发于湿性年龄相关性黄斑变性（nAMD）且每月注射雷珠单抗效果不佳的视网膜色素上皮脱离（DEP）患者的疗效。
这是一项回顾性多中心研究。所有患者均接受3次IAI治疗，然后根据需要每4周治疗一次，持续12个月。在第二年，采用治疗并延长方案对眼睛进行治疗。
共纳入44只眼。在负荷期后（提高3.1±6.4个字母）和6个月时（提高2.8±6.4个字母），最佳矫正视力有显著改善，但在1年和2年时变化不显著。DEP的高度在3个月和6个月时显著降低，但在1年和2年时差异无统计学意义。负荷期后渗出完全消退的眼的比例为59%，2年时为34.3%。转换后抗VEGF注射的平均间隔时间从31±2.6天延长至61±5天。
对于因nAMD导致纤维血管性DEP且每月注射雷珠单抗反应不佳的患者，玻璃体内注射阿柏西普可带来短期的功能和解剖学改善。在长达2年的随访中，玻璃体内注射频率降低。
