Santoso Putra, Maejima Yuko, Kumamoto Kensuke, Takenoshita Seiichi, Shimomura Kenju
aBiology Department, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia bDepartment of Electrophysiology and Oncology cDepartment of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
Neuroreport. 2015 Sep 30;26(14):820-6. doi: 10.1097/WNR.0000000000000431.
ELABELA (ELA) is a novel hormone consisting of 32 amino acid peptides found in humans as well as other vertebrates and is considered to play an important role in the circulatory system through the apelin receptor (APJ). However, whether ELA also acts in the central nervous system remains unknown. Here, we show that ELA functions as an anorexigenic hormone in adult mouse brain. An intracerebroventricular injection of ELA reduces food intake and activates arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN), a hypothalamic region that regulates food intake. Cytosolic calcium ([Ca]i) measurement shows that ELA dose dependently increases [Ca]i in single AVP and CRH-immunoreactive neurons isolated from the PVN. Our data suggest that ELA functions as an anorexigenic hormone through activation of AVP and CRH neurons in the PVN.
艾拉贝拉（ELA）是一种由32个氨基酸肽组成的新型激素，在人类以及其他脊椎动物中均有发现，被认为通过阿片肽受体（APJ）在循环系统中发挥重要作用。然而，ELA是否也在中枢神经系统中起作用仍不清楚。在此，我们表明ELA在成年小鼠大脑中作为一种厌食激素发挥作用。脑室内注射ELA可减少食物摄入量，并激活室旁核（PVN）中的精氨酸加压素（AVP）和促肾上腺皮质激素释放激素（CRH）神经元，PVN是一个调节食物摄入的下丘脑区域。胞质钙（[Ca]i）测量显示，ELA剂量依赖性地增加从PVN分离出的单个AVP和CRH免疫反应性神经元中的[Ca]i。我们的数据表明，ELA通过激活PVN中的AVP和CRH神经元作为一种厌食激素发挥作用。
