Wang Xueying, Liu Xiaofei, Song Zifan, Shen Xin, Lu Siying, Ling Yan, Kuang Haibin
Department of Physiology, Basic Medical College, Nanchang University, Nanchang, China.
Department of Clinical Medicine, School of Queen Mary, Nanchang University, Nanchang, China.
PeerJ. 2020 Nov 11;8:e10245. doi: 10.7717/peerj.10245. eCollection 2020.
APLN, APELA and their common receptor APLNR (composing the apelinergic axis) have been described in various species with extensive body distribution and multiple physiological functions. Recent studies have witnessed emerging intracellular cascades triggered by APLN and APELA which play crucial roles in female reproductive organs, including hypothalamus-pituitary-gonadal axis, ovary, oviduct, uterus and placenta. However, a comprehensive summary of APLN and APELA roles in physiology and pathology of female reproductive system has not been reported to date. In this review, we aim to concentrate on the general characteristics of APLN and APELA, as well as their specific physiological roles in female reproductive system. Meanwhile, the pathological contexts of apelinergic axis dysregulation in the obstetrics and gynecology are also summarized here, suggesting its potential prospect as a diagnostic biomarker and/or therapeutic intervention in the polycystic ovary syndrome, ovarian cancer, preeclampsia and gestational diabetes mellitus.
血管生成素样蛋白（APLN）、血管生成素样蛋白A（APELA）及其共同受体血管生成素样蛋白受体（APLNR）（构成阿片肽能轴）已在多种物种中被描述，它们在体内分布广泛，具有多种生理功能。最近的研究发现，APLN和APELA触发了新出现的细胞内信号级联反应，这些反应在女性生殖器官中发挥着关键作用，包括下丘脑-垂体-性腺轴、卵巢、输卵管、子宫和胎盘。然而，迄今为止，尚未有关于APLN和APELA在女性生殖系统生理和病理方面作用的全面总结报道。在这篇综述中，我们旨在聚焦于APLN和APELA的一般特征，以及它们在女性生殖系统中的特定生理作用。同时，本文还总结了妇产科中阿片肽能轴失调的病理情况，提示其作为多囊卵巢综合征、卵巢癌、先兆子痫和妊娠期糖尿病的诊断生物标志物和/或治疗干预手段的潜在前景。
