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RNA和微小RNA在无创产前诊断中的作用

The Role of RNAs and microRNAs in Non-Invasive Prenatal Diagnosis.

作者信息

Farina Antonio

机构信息

Department of Medicine and Surgery (DIMEC) Division of Prenatal Medicine, University of Bologna, Bologna 40138, Italy.

出版信息

J Clin Med. 2014 May 6;3(2):440-52. doi: 10.3390/jcm3020440.

Abstract

In this paper, all possible clinical applications of circulating mRNA and miRNA for non-invasive prenatal diagnosis appearing in the medical literature so far are described. Data from the literature have also been reported and commented on along with some possible future applications.

摘要

本文描述了迄今为止医学文献中出现的循环mRNA和miRNA在无创产前诊断中的所有可能临床应用。还报告并评论了文献数据以及一些可能的未来应用。

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本文引用的文献

1
Investigation of biological factors influencing the placental mRNA profile in maternal plasma.
Prenat Diagn. 2014 Mar;34(3):251-8. doi: 10.1002/pd.4300. Epub 2014 Jan 10.
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Review: placenta-specific microRNAs in exosomes - good things come in nano-packages.
Placenta. 2014 Feb;35 Suppl:S69-73. doi: 10.1016/j.placenta.2013.11.002. Epub 2013 Nov 15.
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miR-210 inhibits trophoblast invasion and is a serum biomarker for preeclampsia.
Am J Pathol. 2013 Nov;183(5):1437-1445. doi: 10.1016/j.ajpath.2013.07.021. Epub 2013 Sep 10.
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Quantifying mRNA coding growth genes in the maternal circulation to detect fetal growth restriction.
Am J Obstet Gynecol. 2013 Aug;209(2):133.e1-9. doi: 10.1016/j.ajog.2013.04.011. Epub 2013 Apr 10.
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Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations.
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