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慢性血栓栓塞性肺动脉高压的管理进展

Advances in the management of chronic thromboembolic pulmonary hypertension.

作者信息

Papamatheakis Demosthenes G, Kim Nick H

机构信息

Division of Pulmonary and Critical Care Medicine, University of California San Diego, 9300 Campus Point Dr. MC 7381, La Jolla, CA, 92037, USA.

出版信息

Curr Hypertens Rep. 2015 Sep;17(9):582. doi: 10.1007/s11906-015-0582-9.

DOI:10.1007/s11906-015-0582-9
PMID:26239014
Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH), a potentially curable form of pulmonary hypertension with pulmonary thromboendarterectomy surgery, has been the focus of significant medical advances. In addition to new imaging modalities that are now used to help recognize and diagnose CTEPH, additional treatment options have emerged for inoperable cases. These include a newly approved medical therapy for inoperable disease or persistent/recurrent CTEPH as well as percutaneous balloon angioplasty of the pulmonary arteries. In this article, we summarize these recent advances in the field and review the related literature.

摘要

慢性血栓栓塞性肺动脉高压(CTEPH)是一种可通过肺动脉血栓内膜剥脱术治愈的肺动脉高压,一直是重大医学进展的焦点。除了现在用于帮助识别和诊断CTEPH的新成像方式外,对于无法手术的病例也出现了更多的治疗选择。这些包括一种新批准的用于无法手术的疾病或持续性/复发性CTEPH的药物治疗以及肺动脉经皮球囊血管成形术。在本文中,我们总结了该领域的这些最新进展并回顾了相关文献。

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1
Advances in the management of chronic thromboembolic pulmonary hypertension.慢性血栓栓塞性肺动脉高压的管理进展
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2
Treatment of Chronic Thromboembolic Pulmonary Hypertension: The Role of Medical Therapy and Balloon Pulmonary Angioplasty.慢性血栓栓塞性肺动脉高压的治疗:药物治疗和球囊肺动脉血管成形术的作用
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Revisiting a Distinct Entity in Pulmonary Vascular Disease: Chronic Thromboembolic Pulmonary Hypertension (CTEPH).重新审视肺血管疾病中的一个独特实体:慢性血栓栓塞性肺动脉高压(CTEPH)。
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引用本文的文献

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Long-term outcomes of surgery for chronic thromboembolic pulmonary hypertension compared with medical therapy at a single Korean center.韩国一家中心慢性血栓栓塞性肺动脉高压手术与药物治疗的长期疗效比较
Korean J Intern Med. 2017 Sep;32(5):855-864. doi: 10.3904/kjim.2016.049. Epub 2016 Oct 13.
2
[Diagnosis and management of acute pulmonary embolism. ESC guidelines 2014].[急性肺栓塞的诊断与管理。2014年欧洲心脏病学会指南]
Herz. 2015 Dec;40(8):1048-54. doi: 10.1007/s00059-015-4378-0.

本文引用的文献

1
Riociguat for the treatment of chronic thromboembolic pulmonary hypertension: a long-term extension study (CHEST-2).利奥西呱治疗慢性血栓栓塞性肺动脉高压的长期扩展研究(CHEST-2)。
Eur Respir J. 2015 May;45(5):1293-302. doi: 10.1183/09031936.00087114. Epub 2014 Nov 13.
2
Balloon pulmonary angioplasty: an additional treatment option to improve the prognosis of patients with chronic thromboembolic pulmonary hypertension.球囊肺动脉成形术:改善慢性血栓栓塞性肺动脉高压患者预后的另一种治疗选择。
EuroIntervention. 2014 Aug;10(4):518-25. doi: 10.4244/EIJV10I4A89.
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Prevalence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Prevalence of CTEPH after pulmonary embolism.
急性肺栓塞后慢性血栓栓塞性肺动脉高压的患病率。肺栓塞后慢性血栓栓塞性肺动脉高压的患病率。
Thromb Haemost. 2014 Sep 2;112(3):598-605. doi: 10.1160/TH13-07-0538. Epub 2014 Jun 5.
4
Organized thrombus in pulmonary arteries in patients with chronic thromboembolic pulmonary hypertension; imaging with cone beam computed tomography.慢性血栓栓塞性肺动脉高压患者肺动脉内的机化血栓;锥形束计算机断层扫描成像
Jpn J Radiol. 2014 Jul;32(7):375-82. doi: 10.1007/s11604-014-0319-8. Epub 2014 Apr 24.
5
Right ventricular reverse remodelling after balloon pulmonary angioplasty.球囊肺动脉成形术后右心室逆重构。
Eur Respir J. 2014 May;43(5):1394-402. doi: 10.1183/09031936.00012914. Epub 2014 Mar 13.
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Updated clinical classification of pulmonary hypertension.肺动脉高压的最新临床分类。
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D34-41. doi: 10.1016/j.jacc.2013.10.029.
7
3D contrast-enhanced lung perfusion MRI is an effective screening tool for chronic thromboembolic pulmonary hypertension: results from the ASPIRE Registry.3D 对比增强肺部灌注 MRI 是一种有效的慢性血栓栓塞性肺动脉高压筛查工具:ASPIRE 注册研究结果。
Thorax. 2013 Jul;68(7):677-8. doi: 10.1136/thoraxjnl-2012-203020. Epub 2013 Jan 24.
8
Role of 320-slice CT imaging in the diagnostic workup of patients with chronic thromboembolic pulmonary hypertension.320 层 CT 成像在慢性血栓栓塞性肺动脉高压患者诊断中的作用。
Chest. 2013 Apr;143(4):1070-1077. doi: 10.1378/chest.12-0407.
9
Diagnosis of chronic thromboembolic pulmonary hypertension: comparison of ventilation/perfusion scanning and multidetector computed tomography pulmonary angiography with pulmonary angiography.慢性血栓栓塞性肺动脉高压的诊断:通气/灌注扫描及多排螺旋计算机断层扫描肺动脉造影与肺动脉造影的比较
Nucl Med Commun. 2012 May;33(5):459-63. doi: 10.1097/MNM.0b013e32835085d9.
10
Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension.经皮腔内肺血管成形术显著改善慢性血栓栓塞性肺动脉高压患者的肺血流动力学和长期预后。
Circ J. 2012;76(2):485-8. doi: 10.1253/circj.cj-11-1217. Epub 2011 Dec 15.