[排泄管结扎后外分泌胰腺结构变化的形态发生]
[The morphogenesis of the structural changes of the exocrine pancreas after ligation of the excretory duct].
作者信息
Rohrbeck R, Rohrbeck C M, Putzke H P, Jonas L, Reding R
机构信息
Klinik für Chirurgie, Wilhelm-Píeck-Universität und dem Bezirkskrankenhaus, Rostock.
出版信息
Z Exp Chir Transplant Kunstliche Organe. 1989;22(6):371-8.
UNLABELLED
The changes in the exocrine pancreas were investigated after ligature of the excretory duct in 51 Wistar rats. A qualitative microdetermination of the epithelial cells was carried out in the originated ductulus-like structures.
CONCLUSIONS
The acinic epithelial cells grow atrophically first of all and become necrotic in the end. A dedifferentiated acinic cellular atrophy with metamorphosis to a ductulus-like cell type could not be observed. Proliferative and preproliferative events occur in the duct epithelial cells. Cystic ductulus-like structures originated from this. These fill out the former acinic areas by immature, few differentiated, pluripotent epithelial cells that look similar to embryonal pancreatic cells.
未标记
对51只Wistar大鼠的排泄管进行结扎后，研究外分泌胰腺的变化。对所形成的导管样结构中的上皮细胞进行定性微量测定。
结论
腺泡上皮细胞首先发生萎缩性生长，最终坏死。未观察到腺泡细胞去分化萎缩并转变为导管样细胞类型。导管上皮细胞发生增殖和增殖前期事件。由此产生囊性导管样结构。这些结构由不成熟、分化程度低、多能的上皮细胞填充先前的腺泡区域，这些上皮细胞类似于胚胎胰腺细胞。
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