早产儿视网膜病变中的血清中性粒细胞与淋巴细胞比值
Serum neutrophil-to-lymphocyte ratio in retinopathy of prematurity.
作者信息
Kurtul Bengi Ece, Kabatas Emrah Utku, Zenciroglu Aysegul, Ozer Pinar Altiaylik, Ertugrul Gokce Tasdemir, Beken Serdar, Okumus Nurullah
机构信息
Department of Ophthalmology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Department of Ophthalmology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
出版信息
J AAPOS. 2015 Aug;19(4):327-31. doi: 10.1016/j.jaapos.2015.04.008. Epub 2015 Jul 31.
PURPOSE
To evaluate the relationship between serum neutrophil-to-lymphocyte ratio (NLR) and development of retinopathy of prematurity (ROP).
METHODS
Infants with a gestational age of ≤32 week were screened for ROP. Complete blood cell, high-sensitivity C-reactive protein, and interleukin 6 levels of subjects were measured within the first 24 hours of life. The NLR was calculated by dividing neutrophil count by lymphocyte count. The association between other risk factors and the development of ROP were analyzed using univariate analysis and multivariate logistic regression analysis.
RESULTS
A total of 100 infants were included: 80 with ROP and 20 without ROP. The NLR values differed significantly between the ROP group (median, 0.67; interquartile range, 0.38-1.09) and non-ROP group (median, 0.32; interquartile range, 0.22-0.79; P = 0.02). The lymphocyte count in the ROP group (4.01 ± 1.89) compared to that of the non-ROP group (5.69 ± 2.16) was significantly lower (P = 0.001). In multivariate analysis, lymphocyte count remained an independent predictor of ROP (OR = 0.599; 95% CI, 0.430-0.836; P = 0.003).
CONCLUSIONS
The NLR seems not to be an independent predictor of development of ROP. Lymphocyte count is inversely associated with ROP.
目的
评估血清中性粒细胞与淋巴细胞比值（NLR）与早产儿视网膜病变（ROP）发生之间的关系。
方法
对孕周≤32周的婴儿进行ROP筛查。在出生后的头24小时内测量受试者的全血细胞、高敏C反应蛋白和白细胞介素6水平。通过中性粒细胞计数除以淋巴细胞计数来计算NLR。使用单因素分析和多因素逻辑回归分析来分析其他危险因素与ROP发生之间的关联。
结果
共纳入100例婴儿：80例患有ROP，20例未患ROP。ROP组（中位数为0.67；四分位数间距为0.38 - 1.09）和非ROP组（中位数为0.32；四分位数间距为0.22 - 0.79；P = 0.02）的NLR值差异显著。ROP组的淋巴细胞计数（4.01 ± 1.89）与非ROP组（5.69 ± 2.16）相比显著更低（P = 0.001）。在多因素分析中，淋巴细胞计数仍然是ROP的独立预测因素（OR = 0.599；95%CI，0.430 - 0.836；P = 0.003）。
结论
NLR似乎不是ROP发生的独立预测因素。淋巴细胞计数与ROP呈负相关。
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