Cakir Ufuk, Tayman Cuneyt
Ankara Bilkent City Hospital - Division of Neonatology, Department of Pediatrics, Cankaya, Ankara - Turquia.
Arq Bras Cardiol. 2024 Nov;121(11):e20240211. doi: 10.36660/abc.20240211.
Increased oxygen tension and decreased prostaglandin levels cause ductal closure. The diagnostic role of systemic inflammatory indices in hemodynamically significant ductus arteriosus (hsPDA) in premature infants is unknown.
We aimed to evaluate the role of systemic inflammatory indices in the predictivity of hsPDA.
Premature infants with gestational weeks (GW) of <32 weeks were evaluated retrospectively. Systemic inflammatory indices neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), pan-immune- inflammation value (PIV), and systemic inflammation response index (SIRI) were calculated. Systemic inflammatory indices were compared between hsPDA and non-hsPDA groups. A p <0.05 was considered as statistically significant.
A total of 1228 patients were included in the study, including 447 patients in the hsPDA group and 781 patients in the non-hsPDA group. The PIV value [median (Q1 - Q3): 5.18 (2.38-10.42)] in the hsPDA group was statistically significantly higher than the PIV value [median (Q1 - Q3): 3.52 (1.41-6.45)] in the non-hsPDA group (p<0.001). According to the ROC analysis, the AUC value of PIV for the predictivity of hsPDA was 0.618, and the cutoff level was >8.66. After even multiple logistic regression analyses, PIV was shown to be a significant parameter for the diagnosis of hsPDA (OR 1.972, 95% CI 1.114-3.011. p=0.001).
A high PIV value may be a quickly used indicator with low-cost, simple, and easily accessible for the early diagnosis of hsPDA.
氧分压升高和前列腺素水平降低会导致动脉导管关闭。全身炎症指标在早产儿血流动力学显著的动脉导管未闭（hsPDA）中的诊断作用尚不清楚。
我们旨在评估全身炎症指标在hsPDA预测中的作用。
回顾性评估孕周（GW）<32周的早产儿。计算全身炎症指标中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）、血小板与淋巴细胞比值（PLR）、全身免疫炎症指数（SII）、全免疫炎症值（PIV）和全身炎症反应指数（SIRI）。比较hsPDA组和非hsPDA组的全身炎症指标。p<0.05被认为具有统计学意义。
本研究共纳入1228例患者，其中hsPDA组447例，非hsPDA组781例。hsPDA组的PIV值[中位数（Q1 - Q3）：5.18（2.38 - 10.42）]显著高于非hsPDA组的PIV值[中位数（Q1 - Q3）：3.52（1.41 - 6.45）]（p<0.001）。根据ROC分析，PIV对hsPDA预测的AUC值为0.618，截断水平为>8.66。经过多因素logistic回归分析后，PIV被证明是诊断hsPDA的一个重要参数（OR 1.972，95%CI 1.114 - 3.011，p = 0.001）。
高PIV值可能是一种低成本、简单且易于获取的快速用于hsPDA早期诊断的指标。
