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一名患有霍奇金型脑移植后淋巴细胞增生性疾病患者的视网膜脉络膜弓形虫病:一项诊断挑战。

Retinochoroidal toxoplasmosis in a patient with cerebral post-transplant lymphoproliferative disease of Hodgkin's type: a diagnostic challenge.

作者信息

Mittal Ruchi, Thumann Gabrielle, Souteyrand George, Kuerten David, Coupland Sarah E

机构信息

Dalmia Ophthalmic Pathology Services, L.V. Prasad Eye Institute, Bhubaneswar, India,

出版信息

J Ophthalmic Inflamm Infect. 2015 Dec;5(1):55. doi: 10.1186/s12348-015-0055-y. Epub 2015 Aug 4.

DOI:10.1186/s12348-015-0055-y
PMID:26239296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4523567/
Abstract

Toxoplasmosis is a relatively rare complication in renal transplant patients and can pose diagnostic challenges, especially when it manifests as an ocular inflammation. Authors hereby report an unusual case of a 57-year-old male who developed retinochoroidal toxoplasmosis after 15 years of renal transplant, the diagnoses of which were challenging as the patient was also a known case of cerebral post-transplant lymphoproliferative disease (PTLD) of Hodgkin's type, which misled the ophthalmologists towards a clinical diagnosis of ocular PTLD. Histopathology examination of the enucleated eye revealed numerous toxoplasmosis cysts within the retina and choroid. No ocular PTLD was observed.

摘要

弓形虫病在肾移植患者中是一种相对罕见的并发症,可能带来诊断挑战,尤其是当它表现为眼部炎症时。作者在此报告一例不寻常病例,一名57岁男性在肾移植15年后发生视网膜脉络膜弓形虫病,由于该患者也是已知的霍奇金型移植后脑淋巴组织增生性疾病(PTLD)病例,这误导了眼科医生对眼部PTLD的临床诊断,因此该病例的诊断颇具挑战性。摘除眼球的组织病理学检查显示视网膜和脉络膜内有大量弓形虫囊肿。未观察到眼部PTLD。

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本文引用的文献

1
Chorioretinitis as the first sign of acquired toxoplasmosis transmitted from donor following kidney transplantation: case report and review of the literature.脉络膜视网膜炎为肾移植受者来源感染性弓形体病的首发表现:病例报告及文献复习。
Ocul Immunol Inflamm. 2013;21(1):34-5. doi: 10.3109/09273948.2012.726390.
2
Ocular toxoplasmosis II: clinical features, pathology and management.眼弓形体病 II:临床特征、病理学和治疗。
Clin Exp Ophthalmol. 2013 Jan-Feb;41(1):95-108. doi: 10.1111/j.1442-9071.2012.02838.x. Epub 2012 Sep 17.
3
Is it all cerebral toxoplasmosis?
全都是脑弓形虫病吗?
Lancet. 2012 Jan 21;379(9812):286. doi: 10.1016/S0140-6736(11)61579-1.
4
Epstein-Barr virus-associated Hodgkin's disease following renal transplantation.肾移植后与爱泼斯坦-巴尔病毒相关的霍奇金淋巴瘤
Korean J Intern Med. 2006 Mar;21(1):46-9. doi: 10.3904/kjim.2006.21.1.46.
5
Toxoplasmosis after renal transplantation: implications of a missed diagnosis.肾移植后弓形虫病:漏诊的影响
J Clin Microbiol. 2005 Jul;43(7):3544-7. doi: 10.1128/JCM.43.7.3544-3547.2005.