Cai Bo, McDermott Suzanne, Wang Yinding, Royer Julie A, Mann Joshua R, Hardin James W, Ozturk Orgul, Ouyang Lijing
Department of Epidemiology and Biostatistics, University of South Carolina Arnold School of Public Health, Columbia, SC, USA
Department of Epidemiology and Biostatistics, University of South Carolina Arnold School of Public Health, Columbia, SC, USA.
J Child Neurol. 2016 Mar;31(3):370-7. doi: 10.1177/0883073815596611. Epub 2015 Aug 3.
The authors investigated 48 deaths (7% death rate) among 690 adolescents and young adults with spina bifida in South Carolina during 2000-2010. The authors used Medicaid and other administrative data and a retrospective cohort design that included people with spina bifida identified using ICD-9 codes. Cox regression models with time-dependent and time-invariant covariates, and Kaplan-Meier survival curves were constructed. The authors found that 21.4% of the study group had a skin ulcer during the study period and individuals with skin ulcers had significantly higher mortality than those without ulcers (P < .0001). People who had their first skin ulcer during adolescence had higher mortality than those who had the first skin ulcer during young adulthood (P = .0002; hazard ratio = 10.70, 95% confidence interval for hazard ratio: 3.01, 38.00) and those without skin ulcers, controlling for other covariates. This study showed that age at which individuals first had a skin ulcer was associated with mortality.
作者对2000年至2010年期间南卡罗来纳州690名患有脊柱裂的青少年和青年中的48例死亡（死亡率7%）进行了调查。作者使用了医疗补助和其他行政数据，并采用回顾性队列设计，纳入了使用国际疾病分类第九版（ICD-9）编码确定的脊柱裂患者。构建了具有时间依存性和时间非依存性协变量的Cox回归模型以及Kaplan-Meier生存曲线。作者发现，在研究期间，21.4%的研究组患者出现了皮肤溃疡，有皮肤溃疡的个体死亡率显著高于没有溃疡的个体（P <.0001）。在青春期首次出现皮肤溃疡的人死亡率高于在青年期首次出现皮肤溃疡的人（P =.0002；风险比 = 10.70，风险比的95%置信区间：3.01，38.00），在控制其他协变量的情况下，也高于没有皮肤溃疡的人。这项研究表明，个体首次出现皮肤溃疡的年龄与死亡率相关。
