George Emilie, Settler Allison, Connors Scott, Greenfield Jeffrey P
Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, USA.
Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, USA
J Child Neurol. 2016 Mar;31(3):378-87. doi: 10.1177/0883073815596612. Epub 2015 Aug 3.
Gliomatosis cerebri is a rare glial tumor that carries a poor prognosis. Seen in both adults and children, gliomatosis cerebri appears to differ in these populations as with adult versus pediatric glioblastoma. We present 10 children who either presented to the Weill Cornell Medical College or enrolled in the institution's Gliomatosis Cerebri International Registry alongside a cohort of 89 pediatric patients reported in the literature between 2000 and 2014. Age ranged from 4 months to 21 years, with a male to female ratio of 1.71. Median overall survival for patients in the registry cohort was 17 months (n = 10) and for the historic cohort was 13 months (n = 52). Overall survival was analyzed for the combined cohort and was significantly longer when presenting at age ≥ 10 (20 vs 10 months), for boys (18 vs 11 months), and with low-grade pathology (26.5 vs 12 months) but did not vary significantly by treatment approach.
大脑胶质瘤病是一种罕见的胶质肿瘤，预后较差。大脑胶质瘤病在成人和儿童中均可出现，在这两类人群中的表现似乎有所不同，就如同成人与儿童胶质母细胞瘤之间的差异一样。我们报告了10例就诊于威尔康奈尔医学院或加入该机构大脑胶质瘤病国际登记处的儿童患者，同时还有一组2000年至2014年间文献报道的89例儿童患者。年龄范围为4个月至21岁，男女比例为1.71。登记队列患者的中位总生存期为17个月（n = 10），历史队列患者为13个月（n = 52）。对合并队列的总生存期进行了分析，结果显示，年龄≥10岁（20个月对10个月）、男孩（18个月对11个月）以及病理分级较低（26.5个月对12个月）时，总生存期显著更长，但不同治疗方法之间无显著差异。
