用于神经疾病的再生细胞疗法。
Regenerative cellular therapies for neurologic diseases.
作者信息
Levy Michael, Boulis Nicholas, Rao Mahendra, Svendsen Clive N
机构信息
Department of Neurology, Johns Hopkins University, Baltimore, MD, United States.
Department of Neurosurgery, Emory University, Atlanta, GA, United States.
出版信息
Brain Res. 2016 May 1;1638(Pt A):88-96. doi: 10.1016/j.brainres.2015.06.053. Epub 2015 Jul 31.
The promise of stem cell regeneration has been the hope of many neurologic patients with permanent damage to the central nervous system. There are hundreds of stem cell trials worldwide intending to test the regenerative capacity of stem cells in various neurological conditions from Parkinson's disease to multiple sclerosis. Although no stem cell therapy is clinically approved for use in any human disease indication, patients are seeking out trials and asking clinicians for guidance. This review summarizes the current state of regenerative stem cell transplantation divided into seven conditions for which trials are currently active: demyelinating diseases/spinal cord injury, amyotrophic lateral sclerosis, stroke, Parkinson's disease, Huntington's disease, macular degeneration and peripheral nerve diseases. This article is part of a Special Issue entitled SI: PSC and the brain.
干细胞再生的前景一直是许多中枢神经系统遭受永久性损伤的神经疾病患者的希望。全球有数百项干细胞试验，旨在测试干细胞在从帕金森病到多发性硬化症等各种神经疾病中的再生能力。尽管目前尚无干细胞疗法被临床批准用于任何人类疾病适应症，但患者仍在寻找相关试验并向临床医生寻求指导。本综述总结了再生干细胞移植的现状，分为目前正在进行试验的七种疾病：脱髓鞘疾病/脊髓损伤、肌萎缩侧索硬化症、中风、帕金森病、亨廷顿舞蹈症、黄斑变性和周围神经疾病。本文是名为“SI：PSC与大脑”的特刊的一部分。
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