每年接种季节性流感疫苗的中年成年人的血清样本可交叉中和一些潜在的大流行性流感病毒。
Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses.
作者信息
Wang Wei, Alvarado-Facundo Esmeralda, Chen Qiong, Anderson Christine M, Scott Dorothy, Vassell Russell, Weiss Carol D
机构信息
Laboratory of Immunoregulation, Division of Viral Products.
Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
出版信息
J Infect Dis. 2016 Feb 1;213(3):403-6. doi: 10.1093/infdis/jiv407. Epub 2015 Aug 4.
We examined serum samples from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004 to 2009 for cross-neutralizing antibodies to potential pandemic strains. Using pseudoviruses bearing various hemagglutinins (HA-pseudoviruses), we found serum neutralization titers (≥160) in 100% against A/Japan/305/1957 (H2N2), 53% against A/Hong Kong/1073/99 (H9N2), 56% against the H3N2 variant A/Indiana/08/11 (H3N2v), 11% against A/Hong Kong/G9/97 (H9N2), and 36% A/chicken/Hong Kong/SF4/01 (H6N1). None had titers >160 to A/Shanghai/2/13 (H7N9) or A/Netherlands/219/03 (H7N7). Thirty-six percent to 0% had neutralization titers to various H5N1 strains. Titers to H9, H6, and H5 HA-pseudoviruses correlated with each other, but not with H3N2v, suggesting group-specific cross-neutralization.
我们检测了年龄在48至64岁之间的成年人的血清样本，这些人在2004年至2009年期间接种了多种季节性流感疫苗，以检测其针对潜在大流行毒株的交叉中和抗体。使用携带各种血凝素的假病毒（HA假病毒），我们发现血清中和滴度（≥160）在针对A/日本/305/1957（H2N2）时为100%，针对A/香港/1073/99（H9N2）时为53%，针对H3N2变异株A/印第安纳/08/11（H3N2v）时为56%，针对A/香港/G9/97（H9N2）时为11%，针对A/鸡/香港/SF4/01（H6N1）时为36%。没有人针对A/上海/2/13（H7N9）或A/荷兰/219/03（H7N7）的滴度>160。针对各种H5N1毒株的中和滴度在36%至0%之间。针对H9、H6和H5 HA假病毒的滴度相互相关，但与H3N2v不相关，表明存在组特异性交叉中和。
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