Yıldızgören Mustafa Turgut, Rifaioğlu Emine Nur, Demirkapı Musa, Ekiz Timur, Micooğulları Ahmet, Şen Tuğba, Turhanoğlu Ayşe Dicle
Türkocağı St. No: 3 Sıhhiye 06230 Ankara/Turkey.
Cutis. 2015 Jul;96(1):33-6.
The objective of this study was to evaluate the effects of isotretinoin on muscle strength, fatigue, and endurance in patients with acne vulgaris. The study included 27 patients with acne vulgaris who underwent treatment with isotretinoin as well as 26 control patients for comparison. Participants in the treatment group received oral isotretinoin 0.5 mg/kg once daily for 1 month followed by an increased dose of 1 mg/kg once daily for 2 months. Isokinetic measurements were obtained from the hamstrings and quadriceps on the nondominant side of the body at baseline and 3-month follow-up using an isokinetic dynamometer. Results indicated that systemic isotretinoin did not significantly alter muscle strength, fatigue, and endurance.
本研究的目的是评估异维A酸对寻常痤疮患者肌肉力量、疲劳和耐力的影响。该研究纳入了27例接受异维A酸治疗的寻常痤疮患者以及26例作为对照的患者进行比较。治疗组参与者接受口服异维A酸，剂量为0.5mg/kg，每日1次，持续1个月，随后剂量增加至1mg/kg，每日1次，持续2个月。在基线和3个月随访时，使用等速测力计从身体非优势侧的腘绳肌和股四头肌获取等速测量数据。结果表明，全身性异维A酸并未显著改变肌肉力量、疲劳和耐力。
