Ahmad Hesham M
Department of Dermatology and Venereology, Faculty of Medicine, Minia University, Minia, Egypt.
Dermatol Ther. 2015 May-Jun;28(3):151-7. doi: 10.1111/dth.12213. Epub 2015 Mar 5.
Acne vulgaris is a debilitating disorder and requires proper treatment. This work evaluates the clinical efficacy, side effects, and laboratory changes of serum lipids and liver function during oral isotretinoin therapy for acne vulgaris, comparing single versus twice daily dose. Fifty-eight patients with acne vulgaris were included and randomized into group I (26 patients), who received once daily dose, and group II (32 patients), who received twice daily dose of oral isotretinoin. Global acne scoring system was used to evaluate acne severity and post-treatment improvement. Both regimens resulted in highly significant clinical improvement of acne with no significant difference. However, side effects were significantly more common among patients of group I. Both regimens caused mild rise of serum cholesterol, alanine transaminase (ALT), and aspartate aminotransferase (AST) with more prominent rise of triglycerides especially with twice daily dose. Oral isotretinoin is a very effective treatment for acne vulgaris with no statistically significant difference in clinical efficacy between once and twice daily doses. However, dividing dose to twice per day might cause fewer incidence of side effects without reducing clinical efficacy. The drug causes mild clinically insignificant rise of serum cholesterol, triglycerides, AST, and ALT.
寻常痤疮是一种使人虚弱的疾病，需要适当治疗。这项研究评估了口服异维A酸治疗寻常痤疮期间的临床疗效、副作用以及血脂和肝功能的实验室变化，比较了每日一次与每日两次给药剂量。纳入了58例寻常痤疮患者，并随机分为I组（26例患者），接受每日一次给药剂量，和II组（32例患者），接受每日两次口服异维A酸给药剂量。采用全球痤疮评分系统评估痤疮严重程度和治疗后的改善情况。两种治疗方案均使痤疮在临床上得到了高度显著的改善，且无显著差异。然而，I组患者的副作用明显更为常见。两种治疗方案均导致血清胆固醇、丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）轻度升高，甘油三酯升高更为显著，尤其是每日两次给药剂量时。口服异维A酸是治疗寻常痤疮的一种非常有效的药物，每日一次和每日两次给药剂量在临床疗效上无统计学显著差异。然而，将剂量分为每日两次可能会减少副作用的发生率，同时又不降低临床疗效。该药物会使血清胆固醇、甘油三酯、AST和ALT出现轻度的、临床上无显著意义的升高。
