上皮性卵巢癌长期存活者的特征
Characteristics of Long-Term Survivors of Epithelial Ovarian Cancer.
作者信息
Cress Rosemary D, Chen Yingjia S, Morris Cyllene R, Petersen Megan, Leiserowitz Gary S
机构信息
Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, and the Cancer Registry of Greater California, Public Health Institute, the California Cancer Reporting and Epidemiologic Surveillance (CalCARES) Program, Institute for Population Health Improvement, University of California Davis Health System, and the Division of Gynecologic Oncology, University of California Davis Medical Center, Sacramento, California.
出版信息
Obstet Gynecol. 2015 Sep;126(3):491-497. doi: 10.1097/AOG.0000000000000981.
OBJECTIVE
To identify characteristics associated with long-term survival for patients with epithelial ovarian cancer using the California Cancer Registry.
METHODS
A descriptive analysis of survival of all California residents diagnosed with epithelial ovarian cancer between 1994 and 2001 was conducted using patients identified through the cancer registry with follow-up through 2011. Characteristics of the patients who survived more than 10 years (long-term survivors) were compared with three other cohorts: patients who survived less than 2 years, those who survived at least 2 but no more than 5 years, and those who survived at least 5 but no more than 10 years.
RESULTS
A total of 3,582 out of 11,541 (31%, confidence interval 30.2-31.8%) of the patients survived more than 10 years. Younger age, early stage, low-grade, and nonserous histology were significant predictors of long-term survival, but long-term survivors also included women with high-risk cancer.
CONCLUSION
Long-term survival is not unusual in patients with epithelial ovarian cancer, even in those with high-risk disease. Many of the prognostic factors are well known, but it remains to be determined why some patients with advanced-stage high-grade cancers survive longer than others with the same histology. These findings are important for patient counseling.
LEVEL OF EVIDENCE
III.
目的
利用加利福尼亚癌症登记处的数据，确定上皮性卵巢癌患者长期生存相关的特征。
方法
对1994年至2001年间在加利福尼亚州被诊断为上皮性卵巢癌的所有居民的生存情况进行描述性分析，研究对象通过癌症登记处确定，并随访至2011年。将存活超过10年的患者（长期存活者）的特征与其他三组患者进行比较：存活少于2年的患者、存活至少2年但不超过5年的患者以及存活至少5年但不超过10年的患者。
结果
11,541名患者中共有3,582名（31%，置信区间30.2 - 31.8%）存活超过10年。年龄较小、分期较早、分级较低和非浆液性组织学是长期生存的显著预测因素，但长期存活者中也包括患有高危癌症的女性。
结论
上皮性卵巢癌患者长期生存并不罕见，即使是患有高危疾病的患者。许多预后因素是众所周知的，但仍有待确定为什么一些晚期高级别癌症患者比具有相同组织学类型的其他患者存活时间更长。这些发现对患者咨询很重要。
证据级别
III级。
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