Le Song Thi, Asahara Haruyasu, Nishiwaki Nagatoshi
School of Environmental Science and Engineering, and ‡Research Center for Material Science and Engineering, Kochi University of Technology , Tosayamada, Kami, Kochi 782-8502, Japan.
J Org Chem. 2015 Sep 4;80(17):8856-8. doi: 10.1021/acs.joc.5b01391. Epub 2015 Aug 19.
An alternative method for the synthesis of 3-alkylated/arylated 5-nitropyridines was developed involving a three-component ring transformation of 3,5-dinitro-2-pyridone on treatment with aldehyde in the presence of ammonium acetate. This method facilitates the modification of the substituent at the 3-position by changing the precursor aldehyde. The use of solid ammonium acetate instead of ammonia as the nitrogen source renders the synthetic method more practical and user-friendly.
