具有高度可调机械性能和降解性能的新型生物相容性弹性体星形肌醇基聚合物的光交联制备
Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation.
作者信息
Xie Meihua, Ge Juan, Xue Yumeng, Du Yuzhang, Lei Bo, Ma Peter X
机构信息
Frontier Institute of Science and Technology, Xi׳an Jiaotong University, Xi׳an, China.
Frontier Institute of Science and Technology, Xi׳an Jiaotong University, Xi׳an, China; State Key Laboratory for Manufacturing Systems Engineering, Xi׳an Jiaotong University, Xi׳an, China; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, China.
出版信息
J Mech Behav Biomed Mater. 2015 Nov;51:163-8. doi: 10.1016/j.jmbbm.2015.07.011. Epub 2015 Jul 26.
Biodegradable and star-shaped polymers with highly tunable structure and properties have attracted much attention in recent years for potential biomedical applications, due to their special structure. Here, inositol-based star-shaped poly-L-lactide-poly(ethylene glycol) (INO-PLLA-PEG) biomedical polymer implants were for the first time synthesized by a facile photo-crosslinking method. This biomaterials show controlled elastomeric mechanical properties (~18 MPa in tensile strength, ~200 MPa in modulus, ~200% in elongation), biodegradability and osteoblasts biocompatibility. These results make INO-PLLA-PEG implants highly promising for bone tissue regeneration and drug delivery applications.
近年来，具有高度可调节结构和性能的可生物降解星形聚合物因其特殊结构在潜在生物医学应用中备受关注。在此，首次通过简便的光交联方法合成了基于肌醇的星形聚-L-丙交酯-聚（乙二醇）（INO-PLLA-PEG）生物医学聚合物植入物。这种生物材料具有可控的弹性体机械性能（拉伸强度约为18 MPa，模量约为200 MPa，伸长率约为200%）、生物可降解性和成骨细胞生物相容性。这些结果使得INO-PLLA-PEG植入物在骨组织再生和药物递送应用方面极具前景。
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