Faculty of Pharmacy, Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247 University of Montpellier 1, University of Montpellier 2, 15 Av. C. Flahault, Montpellier 34093, France.
Biomed Mater. 2011 Dec;6(6):065006. doi: 10.1088/1748-6041/6/6/065006. Epub 2011 Nov 21.
Although desirable for biomedical applications, soft degradable elastomers having balanced amphiphilic behaviour are rarely described in the literature. Indeed, mainly highly hydrophobic elastomers or very hydrophilic elastomers with hydrogel behaviours are found. In this work, we developed thermoset degradable elastomers based on the photo-cross-linking of poly(lactide)-poly(ethylene glycol)-poly(lactide) (PLA-PEG-PLA) triblock prepolymers. The originality of the proposed elastomers comes from the careful choice of the prepolymer amphiphilicity and from the possible modulation of their mechanical properties and degradation rates provided by cross-linkers of different nature. This is illustrated with the hydrophobic and rigid 2,4,6-triallyloxy-1,3,5-triazine compared to the hydrophilic and soft pentaerythritol triallyl ether. Thermal properties, mechanical properties, swelling behaviours, degradation rates and cytocompatibility have been evaluated. Results show that it is possible to generate a family of degradable elastomers covering a broad range of properties from a single biocompatible and biodegradable prepolymer.
尽管在生物医学应用中是理想的，但具有平衡的两亲性行为的软可降解弹性体在文献中很少被描述。实际上，主要发现的是高度疏水性弹性体或具有水凝胶行为的非常亲水性弹性体。在这项工作中，我们开发了基于聚（乳酸）-聚（乙二醇）-聚（乳酸）（PLA-PEG-PLA）三嵌段预聚物的光交联的热固性可降解弹性体。所提出的弹性体的新颖性来自于预聚物两亲性的精心选择，以及通过不同性质的交联剂来调节其机械性能和降解速率的可能性。这可以通过疏水性和刚性的 2,4,6-三丙烯酰氧基-1,3,5-三嗪与亲水性和柔软的季戊四醇三烯丙基醚进行比较来说明。已经评估了热性能、机械性能、溶胀行为、降解速率和细胞相容性。结果表明，有可能从单一的生物相容性和可生物降解的预聚物生成覆盖广泛性能的可降解弹性体家族。
