Shimura Tadanobu, Toiyama Yuji, Tanaka Koji, Saigusa Susumu, Kitajima Takahito, Kondo Satoru, Okigami Masato, Yasuda Hiromi, Ohi Masaki, Araki Toshimitsu, Inoue Yasuhiro, Uchida Keiichi, Mohri Yasuhiko, Kusunoki Masato
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Anticancer Res. 2015 Sep;35(9):4633-9.
Angiopoietin-like protein-2 (ANGPTL2) mediates chronic inflammation. Tumor cell-derived ANGPTL2 promotes tumor invasion and angiogenesis. ANGPTL2 expression has not been fully investigated in gastric cancer (GC).
ANGPTL2 expression in 354 patients with GC was assessed by immunohistochemistry (IHC). IHC scores were calculated, and the association of ANGPTL2 with clinicopathological factors and patient outcomes was evaluated.
Immunoreactive ANGPTL2 protein was expressed mainly in GC cell cytoplasm. Kaplan-Meier analysis showed that high expression of ANGPTL2 indicated significantly poorer overall disease-free survival (DFS). Among patients with curatively resected GC, multivariate analysis for DFS revealed that high ANGPTL2 expression (p<0.01), advanced T-stage (p=0.015), lymph node metastasis (p<0.01), and advanced Unio Internationalis Contra Cancrum (UICC) stage (p<0.01) were independent risk factors for poor DFS.
High cytoplasmic ANGPTL2 expression in GC tissue was associated with tumor progression, invasion, metastasis, and poor prognosis. ANGPTL2 may be a useful marker for detecting early postoperative recurrence in patients with GC.
血管生成素样蛋白2（ANGPTL2）介导慢性炎症。肿瘤细胞衍生的ANGPTL2促进肿瘤侵袭和血管生成。ANGPTL2在胃癌（GC）中的表达尚未得到充分研究。
采用免疫组织化学（IHC）方法评估354例GC患者中ANGPTL2的表达。计算IHC评分，并评估ANGPTL2与临床病理因素及患者预后的相关性。
免疫反应性ANGPTL2蛋白主要表达于GC细胞胞质中。Kaplan-Meier分析显示，ANGPTL2高表达表明总体无病生存期（DFS）显著较差。在接受根治性切除的GC患者中，DFS的多因素分析显示，ANGPTL2高表达（p<0.01）、T分期进展（p=0.015）、淋巴结转移（p<0.01）和国际抗癌联盟（UICC）分期进展（p<0.01）是DFS不良的独立危险因素。
GC组织中ANGPTL2高细胞质表达与肿瘤进展、侵袭、转移及预后不良相关。ANGPTL2可能是检测GC患者术后早期复发的有用标志物。
