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将丘脑室旁核置于控制行为的大脑回路中。

Placing the paraventricular nucleus of the thalamus within the brain circuits that control behavior.

机构信息

Departments of Oral Biology and Psychiatry, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

出版信息

Neurosci Biobehav Rev. 2015 Sep;56:315-29. doi: 10.1016/j.neubiorev.2015.08.005. Epub 2015 Aug 7.

Abstract

This article reviews the anatomical connections of the paraventricular nucleus of the thalamus (PVT) and discusses some of the connections by which the PVT could influence behavior. The PVT receives neurochemically diverse projections from the brainstem and hypothalamus with an especially strong innervation from peptide producing neurons. Anatomical evidence is also presented which suggests that the PVT relays information from neurons involved in visceral or homeostatic functions. In turn, the PVT is a major source of projections to the nucleus accumbens, the bed nucleus of the stria terminalis and the central nucleus of the amygdala as well as the cortical areas associated with these subcortical regions. The PVT is activated by conditions and cues that produce states of arousal including those with appetitive or aversive emotional valences. The paper focuses on the potential contribution of the PVT to circadian rhythms, fear, anxiety, food intake and drug-seeking. The information in this paper highlights the potential importance of the PVT as being a component of the brain circuits that regulate reward and defensive behavior with the hope of generating more research in this relatively understudied region of the brain.

摘要

这篇文章回顾了丘脑室旁核(PVT)的解剖连接,并讨论了一些 PVT 可能影响行为的连接。PVT 接收来自脑干和下丘脑的神经化学多样化投射,特别是来自产生肽的神经元的强烈支配。还提出了解剖学证据,表明 PVT 传递参与内脏或稳态功能的神经元的信息。反过来,PVT 是向伏隔核、终纹床核和杏仁核中央核以及与这些皮质区域相关的皮质区域投射的主要来源。PVT 被产生觉醒状态的条件和线索激活,包括具有食欲或厌恶情绪的状态。本文重点介绍了 PVT 对昼夜节律、恐惧、焦虑、食物摄入和觅药的潜在贡献。本文中的信息突出了 PVT 作为调节奖励和防御行为的大脑回路的一个组成部分的重要性,希望在这个相对研究较少的大脑区域产生更多的研究。

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