Ichhpujani Parul, Lo David C, Cvintal Victor, Waisbourd Michael, Averbuch Adam, Leiby Benjamin E, Myers Jonathan S, Spaeth George L, Katz L Jay
Glaucoma Research Center, Wills Eye Hospital.
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pa.
Can J Ophthalmol. 2015 Aug;50(4):290-6. doi: 10.1016/j.jcjo.2015.05.010.
To compare flicker defined form (FDF) perimetry using the Heidelberg edge perimeter (HEP) with standard automated perimetry (SAP) on the Humphrey visual field (HVF) analyzer and to compare their relationship to structural measurements acquired with the Heidelberg retina tomograph.
Prospective, observational study.
Thirty-one glaucomatous eyes with varying severity and 13 normal control eyes were included in this analysis.
All subjects underwent FDF testing on the HEP using the 24-2 protocol by the adaptive staircase thresholding algorithm standard strategy and SAP on the HVF analyzer 750 II using the SITA-Standard 24-2 test. Heidelberg retina tomography (HRT) testing was obtained for each patient. Spearman correlation coefficient, mean deviation (MD), and pattern standard deviation measurements by both machines were compared.
FDF and SAP MD were significantly correlated (r = 0.81, p < 0.001). FDF and SAP MD were significantly correlated with HRT cup/disc ratio (FDF MD: p < 0.001; SAP MD: p = 0.003), disc area (FDF MD: p = 0.005; SAP MD: p = 0.059), rim volume (FDF MD: p < 0.001; SAP MD: p < 0.001), and retinal nerve fibre layer (FDF MD: p < 0.001; SAP MD: p < 0.001).
This pilot study shows that the MD parameter of FDF correlated with SAP results. FDF and SAP had significant correlations with HRT parameters in glaucomatous and healthy eyes. The potential utility of FDF in the clinical management of glaucoma requires further investigation.
在汉弗莱视野（HVF）分析仪上，比较使用海德堡周边视野计（HEP）的闪烁定义视野（FDF）检查法与标准自动视野计（SAP），并比较它们与通过海德堡视网膜断层扫描仪获取的结构测量值之间的关系。
前瞻性观察性研究。
本分析纳入了31只不同严重程度的青光眼患眼和13只正常对照眼。
所有受试者均通过自适应阶梯阈值算法标准策略，在HEP上采用24-2程序进行FDF检查，并在HVF分析仪750 II上采用SITA-标准24-2测试进行SAP检查。对每位患者进行海德堡视网膜断层扫描（HRT）检查。比较两台仪器的斯皮尔曼相关系数、平均偏差（MD）和模式标准偏差测量值。
FDF和SAP的MD显著相关（r = 0.81，p < 0.001）。FDF和SAP的MD与HRT杯盘比显著相关（FDF MD：p < 0.001；SAP MD：p = 0.003）、视盘面积（FDF MD：p = 0.005；SAP MD：p = 0.059）、视盘边缘体积（FDF MD：p < 0.001；SAP MD：p < 0.001）以及视网膜神经纤维层（FDF MD：p < 0.001；SAP MD：p < 0.001）。
这项初步研究表明，FDF的MD参数与SAP结果相关。FDF和SAP在青光眼患眼和健康眼中与HRT参数均有显著相关性。FDF在青光眼临床管理中的潜在效用需要进一步研究。
